<description>&lt;p class="MsoNormal"&gt;&lt;span style= "font-size: 12.0pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: #333333;"&gt; Dr. Ian Kelleher (University of Edinburgh, Scotland) joins &lt;em&gt;AJP Audio&lt;/em&gt; to discuss &lt;a href= "https://psychiatryonline.org/doi/10.1176/appi.ajp.20240958" target="_blank" rel="noopener"&gt;an emulated target trial&lt;/a&gt; looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder.&lt;span style="mso-spacerun: yes;"&gt; &lt;/span&gt; Afterwards, &lt;em&gt;AJP&lt;/em&gt; Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.&lt;/span&gt;&lt;/p&gt; &lt;ul&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 00:53&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Doxycycline and the risk of developing schizophrenia&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 04:03&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Emulated target trials versus randomized control trials&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 06:43&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Methods of action&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 09:24&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Dosage and exposure levels for doxycycline&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 10:15&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Immediate clinical applications&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 10:56&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Limitations of the study&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 11:33&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Future research&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 12:43&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Kalin interview&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 13:00&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; &lt;a href= "https://doi.org/10.1176/appi.ajp.20240958"&gt;Lång et al.&lt;/a&gt;&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 19:43&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; &lt;a href= "https://doi.org/10.1176/appi.ajp.20250111"&gt;Zhao et al.&lt;/a&gt;&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 25:20&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; &lt;a href= "https://doi.org/10.1176/appi.ajp.20250115"&gt;Metrik et al.&lt;/a&gt;&lt;/span&gt;&lt;/li&gt; &lt;/ul&gt; &lt;p class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black; mso-color-alt: windowtext;"&gt; &lt;a href= "https://psychiatryonline.org/pb-assets/podcasts/transcripts/AJP/AJP_Audio_Kelleher_February_2026_transcript.pdf" target="_blank" rel="noopener"&gt;Transcript&lt;/a&gt;&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: #333333;"&gt; Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; 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American Journal of Psychiatry Audio

American Journal of Psychiatry

February 2026: Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial

FEB 1, 202629 MIN
American Journal of Psychiatry Audio

February 2026: Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial

FEB 1, 202629 MIN

Description

Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:53 Doxycycline and the risk of developing schizophrenia 04:03 Emulated target trials versus randomized control trials 06:43 Methods of action 09:24 Dosage and exposure levels for doxycycline 10:15 Immediate clinical applications 10:56 Limitations of the study 11:33 Future research 12:43 Kalin interview 13:00 Lång et al. 19:43 Zhao et al. 25:20 Metrik et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]