This Week in Startups

This Week In Startups is made possible by:Quo - https://quo.com/TWiSTLinkedIn Jobs - https://LinkedIn.com/twistIru - https://iru.com/twistPlaud - https://Plaud.ai/twistToday’s show:Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters.He joins Jason and Lon to walk us through his 5-step framework for designing an efficient AI agent team:Start with one agent and onboard them like a new hireStop Googling fixes; just ask your agent how to use itPut your agents on fixed schedulesAdd shared memory so you don’t have to repeat yourselfLet agents run self-reviews and rewrite their own instructions.Get the walkthrough to put this entire plan into practice on today’s episode. PLUS fresh demos of the “Minecraft”-inspired virtual workspace MoltWorld and AgentMail, which is Gmail for your AI pals, and Jason explains the thinking behind his viral, controversy-stirring “don’t talk to journalists” tweet.Follow Shubham: https://x.com/Saboo_Shubham_“How I Built an Autonomous AI Agent Team That Runs 24/7” on X: https://x.com/Saboo_Shubham_/status/2022014147450614038?s=20Follow Mike: https://x.com/mihalich1988MoltWorld: https://moltworld.io/Follow Haakam: https://x.com/haakamaujlaAgentMail: https://www.agentmail.to/Jason’s post about talking to journalists: https://x.com/Jason/status/2037573025458016659NYT responds: https://x.com/NYTimesPR/status/2037648223771263082Translated Japanese tweets: https://x.com/melonneet40/status/2038020624015315289, https://x.com/rambling_28/status/2038041455999246422Japanese people singing “Country Roads”: https://x.com/harukaawake/status/2038081269830222259Trailer for “Nuremberg” (now on Netflix in the US): https://www.youtube.com/watch?v=WvAy9C-bipYTimestamps:0:00 Intro1:24 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:05 We're Claw-pilled once again; it's an all AI Agent showcase6:15 Google AI PM Shubham Saboo's Top 5 OpenClaw tips10:14 Quo (formerly OpenPhone) gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST.13:26 Tip #1 — Onboard your agent like a new hire17:31 Tip #2 — Talk to your agents constantly19:02 Tip #3 — Put your agents on a schedule19:51 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist.23:41 Tip #4 — Add cross-agent memory29:33 Tip #5 — Let your agents self-improve29:51 Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at https://iru.com/twist!34:03 Why Jason says founders should avoid journalists38:24 How biased IS the New York Times?47:02 DEMO: Co-founder Mike Nosov shows us MoltWorld51:14 But what's the utility of this?1:05:15 DEMO: Haakam Aujla presents AgentMail (YC S25)1:09:59 How does AgentMail make money?1:17:03 How Grok Translations are creating cross-cultural dialogue on XSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanis

This Week In Startups is made possible by:Wispr Flow - https://wisprflow.ai/twistCircle - http://circle.so/twistDeel - http://deel.com/twistToday’s show:AstroForge is building low-cost, replicable spacecraft to mine platinum group metals from near-Earth asteroids — a $60 billion annual market for materials that are running out on Earth. Founder and CEO Matt Gialich joins the show to talk about the company's ambitious mission, what went wrong on their first two flights, and why Mission 3 could still change everything.PLUS Sam Dare from Templar stops by to talk about training AI models on a decentralized blockchain, and why it’s so much cheaper and more efficient than the conventional “data center full of GPUs” method. AND a demo of OpenOats from creator Yazin Alirhayim of his open source Granola alternative.Astroforge: https://www.astroforge.com/Templar: https://www.tplr.ai/Epoch AI decentralized training post: https://epoch.ai/gradient-updates/how-far-can-decentralized-training-over-the-internet-scaleOpenOats on Github: https://github.com/yazinsai/OpenOatsTimestamps:0:00 Intro0:59 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:05 We aplaud Plaud!3:18 Astroforge is mining… asteroids?!6:11 How creating an abundance of Platinum will impact Humanity!9:56 Wispr Flow: Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit https://wisprflow.ai/twist to get started for free today.21:16 Circle: The easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to https://circle.so/twist.22:01 How Astroforge uses capitalism to unlock abundance24:35 J-Cal subscribed to… A socialist magazine?26:19 Sam Dare of Templar joins the show!27:47 What is TAO doing that's uniquely different from Bitcoin30:15 What is the incentive mechanism that Templar uses?30:44 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.37:49 How much does it cost to run templar's model?45:16 Can decentralized training over the internet scale? https://epoch.ai/gradient-updates/how-far-can-decentralized-training-over-the-internet-scale47:16 Jason addresses his tao investment48:48 Why brand is the moat for startups49:47 When will a better, more exciting version of Bitcoin, can come along?52:20 Yazin of OpenGranola Joins the show53:36 How OpenGranola has local LLM's taking notes for you and giving you real time insights in your meeting!1:01:45 Jason's callout for a sidebar that shows all inputs from agents1:13:50 The economics of the new harry potter series and HBO/ Warner Brothers1:23:33 Why Jason wants government surveillance on Disney adults…Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Luma AI - https://lumalabs.ai/twistEvery.io -  https://every.ioLemon.io - https://Lemon.io/twistPlaud - https://Plaud.ai/twistToday’s show:What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor network to get more work done, more quickly, in a completely decentralized fashion.Metanova uses its subnet to run developer competitions to find exciting molecular candidates, parsing through a mountain of possibilities to pluck out the most promising for further investigation.Bitcast uses its subnet to collect visibility demand from brands, which is served by video creators. The company is focused on the crypto niche to start, but will expand in time to other technology topics.Score uses its subnet to generate highly performant, specialized vision models, which it then sells to customers through a platform (Manako).In each case, the Bittensor’s economic engine unlocks global creativity to tackle tasks that were previously time-consuming, fragmented, or expensive to complete. Let’s see how quickly each company can scale and whether startups building on Bittensor can grow faster than their non-decentralized peers.Timestamps:0:00 Intro2:19 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:40 What is Bittensor?7:22 Metanova Labs joins the show9:28 Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist17:16 How Metanova tackles the multi-billion dollar cost of drug discovery20:48 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io30:20 Bitcast joins the show31:23 Luma AI - Luma builds accessible, professional-grade AI tools for creatives. Try Luma Agents for free at https://lumalabs.ai/twist32:30 Mining crypto with YouTube36:48 Why Bitcast is focused on the crypto space to start39:11 How healthy is the creator economy?47:26 When will the AI bubble collapse?53:44 Score joins the show54:42 How Score will make vision AI more accessible57:16 VLMs v. LLMs1:01:14 Demo of the Manako platformSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week in AI sneak peak! If you enjoy the episode find us on Spotify, Apple podcasts and YouTube by looking up "This Week in AI" or by going to thisweekinai.aiThis week Jason sat down with Jake Loosararian and Chris Lattner on Episode 6 of This Week in AI. Jake is the CEO and co-founder of Gecko Robotics, a company deploying purpose-built robots and AI for mission-critical infrastructure inspection across energy, defense, and manufacturing. Chris is the CEO and co-founder of Modular, building a universal software layer that lets developers run AI models across Nvidia, AMD, and Apple silicon without being locked into any single hardware vendor.We explore the GPU shortage, why China's chip smuggling reveals the stakes of the AI cold war, how purpose-built robotics are beating humanoids on ROI, the case for American reindustrialization, and why the next decade could be the best ever for private equity in capital-intensive industries.Purpose-Built Robots vs. Humanoids: Jake has been building mission-critical robots for 13 years. He explains why general-purpose humanoids still have too little ROI for industrial use, and why specialized robots that find and fix problems are winning in the field.The GPU Shortage Is Real: Chris breaks down why you can't just go buy 100 Blackwell chips today, why Nvidia's Cuda creates massive lock-in, and how Modular is building a unified software layer across all major chip architectures.Google TPUs Are the Sleeper: Chris ranks Google as the number one threat to Nvidia's dominance, ahead of Amazon's Trainium and AMD.China's Chip Smuggling & the AI Cold War: A Supermicro co-founder allegedly smuggled $2.5B in Nvidia chips to China using fake serial numbers and a hairdryer. The Best Decade for Private Equity: Jake makes the case that capital-intensive, commoditized infrastructure assets: waste-to-energy, water treatment, old power plants will all generate incredible returns.Self-Driving State of Play: Chris, a former Tesla Autopilot lead, gives his read on Waymo's lead, Tesla's small Austin pilot, and why the real signal is when Tesla starts filing for fully autonomous permits in California.Learn more about Gecko Robotics: https://www.geckorobotics.comLearn more about Modular: https://www.modular.com/This Week In AI is made possible by:*PayPalOpen* - One Platform for all Business: paypalopen.com*Timestamps:*00:00 Welcome & intro to Jake Lu (Gecko Robotics) and Chris Lattner (Modular)01:34 Gecko's 13-year journey & the Cantilever platform05:15 Chris Lattner on Modular: replacing Cuda & unifying AI hardware11:10 Nvidia lock-in, AMD's Rock & why the software stack is broken19:49 The GPU shortage: how real is it?22:13 Who challenges Nvidia? Google TPUs, Amazon Trainium & AMD ranked28:17 China chip smuggling: $2.5B in Nvidia GPUs & the AI cold war37:43 Self-driving update: Waymo, Tesla's Austin pilot & Chris's Tesla history42:20 Figure's humanoid package sorting — real or demo magic?43:47 The best decade for private equity in capital-intensive assets51:04 Reindustrialization, the trades boom & making manufacturing cool58:39 Building tech companies outside Silicon Valley1:06:46 Breaking news: Brett Adcock launches Hark from Figure1:10:15 Closing thoughts: grit over hype, customers over valuationsSubscribe to This Week in AI on Apple: https://thisweekinai.ai/spotifySubscribe to This Week in AI on Spotify: https://thisweekinai.ai/appleThanks for watching!🤖 If you want to stay ahead of the curve on all things AI, make sure to join our community across all platforms:📩 Get the Weekly Newsletter: https://thisweekinai.ai/📺 Subscribe on YouTube: https://www.youtube.com/@ThisWeekinAIPodcast📸 Instagram: https://www.instagram.com/thisweekinaipodcast📱 TikTok: https://www.tiktok.com/@thisweekinaipodcast✖️X: https://x.com/ThisWeeknAIFollow Jason:X: https://twitter.com/JasonFollow Oliver:https://x.com/oliverkorzen

This Week In Startups is made possible by:Northwest Registered Agent - https://northwestregisteredagent.com/twistLinkedIn Jobs - https://linkedIn.com/twistSentry - https://sentry.io/twistPlaud - http://Plaud.ai/twistRo.co - http://Ro.co/TwistToday’s show:Hustle Fund general partner Elizabeth Yin joined Jason and Alex to discuss how rapid advances in AI have changed the venture capital game, and how the same AI updates are changing how founders build. Founders may need less capital than before, which could reduce their reliance on venture dollars over time.Ceel founder Ryan Mahdavi joined next to help Jason and Alex dig into the Delve story. Well-funded Delve was publicly criticized for allegedly overselling their compliance tool’s capabilities and not being honest with customers. Delve has responded to the allegations, though Mahdavi said that he had his doubts about the competing startup even before the news story broke.Next, TWiST invited Brick founder Seg Sheng on to explain his startup’s plan to use a combination of physical hardware and artificial intelligence to help buildings and data centers reduce their energy bills. Given how much juice the AI era demands, Brick could be onto something big.And to close out the show, Gavin Zaentz and Pranav Ramesh from LeadPoet (Bittensor Subnet 71) to show off their technology (the pair put in motion a lead hunt for Brick while on-air). It’s a packed show with something for everyone. Let’s go!Timestamps:0:00 Intro1:18 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:45 Elizabeth Yin from Hustle Fund on how AI tools have changed her workflow9:21 How founders use AI to learn how to suck less10:34 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST13:17 Ryan Mahdavi from Ceel joins to explain the Delve SOC 2 scandal18:39 Is Silicon Valley's "bend the rules" culture at fault?20:38 Red and pink flags, and how investors can spot potential fraud21:41 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist23:45 How to not do securities fraud: a simple guide26:50 Ryan asks: How did the company get through diligence?31:03 Northwest Registered Agent — Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist32:25 Were there early warning signs about issues with Delve?33:26 On Delve's use of tactical donuts36:55 What about the Delve board? If there is one?45:24 Seb Sheng stops by to tell us about how Brick Data saves companies massively on energy costs49:38 Who are Brick's customers and how much are they paying?54:16 Lightning Round: A quick history of Brick56:02 Why Jason is so bullish on $TAO56:45 Ro.co: Ro's insurance checker will let you know if your coverage includes GLP-1s for FREE. Go to https://Ro.co/Twist for your free insurance check.1:06:35 How do LeadPoet's "miners" track down the best leads?1:13:09 How Bittensor subnets map to traditional startup forms1:17:15 How can agents build up authority if they can't get hired for their first job?1:21:03 Jason: "I think the game of Bitcoin has ended…"1:23:22 Why Jason likes to place a bet, then learn1:24:16 The inherent risks in crypto investmentSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out Jason’s suite of newsletters: https://substack.com/@calacanis