TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: <a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://www.parasiteswithoutborders.com/">Daniel Griffin</a>, and Christina Naula Subscribe (free): <a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz">Google Podcasts</a>, <a href= "http://twip.microbeworld.libsynpro.com/rss">RSS</a>, <a href= "http://eepurl.com/Gcw59">email</a> Links for this episode <ul class="wp-block-list"> <li>Join the MicrobeTV <a title="" href= "https://discord.gg/vmnCyBPQds">Discord server</a></li> <li>Naegleria fowleri acquired at <a title="" href= "https://www.cdc.gov/mmwr/volumes/74/wr/mm7410a2.htm?s_cid=mm7410a2_w">splash pad</a> (MMWR)</li> <li>Determinants of P. falciparum <a title="" href="https://doi.org/10.1126/science.adk9893">drug resistance</a> (Science)</li> <li><a title="" href= "https://www.cambridge.org/core/journals/parasitology/article/paleoparasitological-analysis-of-a-15th16th-c-ce-latrine-from-the-merchant-quarter-of-bruges-belgium-evidence-for-local-and-exotic-parasite-infections/0129A058DBFF38CF7A4E9882206B7949"> Paleoparasitological analysis</a> of 5th–16th c. CE latrine (Parasitol)</li> </ul> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiP  Send your questions and comments to <a href= "mailto:twip@microbe.tv">twip@microbe.tv</a> Music by <a href="http://www.ronaldjenkees.com/">Ronald Jenkees</a>

<description>&lt;p&gt;TWiP explains a study that carries out selection of &lt;em&gt;Plasmodium falciparum&lt;/em&gt; in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine.&lt;/p&gt; &lt;p&gt;Hosts: &lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;&lt;strong&gt;Vincent Racaniello&lt;/strong&gt;&lt;/a&gt;, &lt;a title="" href= "http://www.parasiteswithoutborders.com/"&gt;&lt;strong&gt;Daniel Griffin&lt;/strong&gt;&lt;/a&gt;, and Christina Naula&lt;/p&gt; &lt;p&gt;Subscribe (free): &lt;a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495"&gt;Apple Podcasts&lt;/a&gt;, &lt;a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz"&gt;Google Podcasts&lt;/a&gt;, &lt;a href= "http://twip.microbeworld.libsynpro.com/rss"&gt;RSS&lt;/a&gt;, &lt;a href= "http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;&lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;Join the MicrobeTV &lt;a title="" href= "https://discord.gg/vmnCyBPQds"&gt;Discord server&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;em&gt;Naegleria fowleri&lt;/em&gt; acquired at &lt;a title="" href= "https://www.cdc.gov/mmwr/volumes/74/wr/mm7410a2.htm?s_cid=mm7410a2_w"&gt;splash pad&lt;/a&gt; (MMWR)&lt;/li&gt; &lt;li&gt;Determinants of &lt;em&gt;P. falciparum&lt;/em&gt; &lt;a title="" href="https://doi.org/10.1126/science.adk9893"&gt;drug resistance&lt;/a&gt; (Science)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.cambridge.org/core/journals/parasitology/article/paleoparasitological-analysis-of-a-15th16th-c-ce-latrine-from-the-merchant-quarter-of-bruges-belgium-evidence-for-local-and-exotic-parasite-infections/0129A058DBFF38CF7A4E9882206B7949"&gt; Paleoparasitological analysis&lt;/a&gt; of 5th–16th c. CE latrine (Parasitol)&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiP &lt;/p&gt; &lt;p&gt;Send your questions and comments to &lt;a href= "mailto:twip@microbe.tv"&gt;twip@microbe.tv&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Music by &lt;a href="http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt;</description>

TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: , , and...

TWiP 256: Amazing antimalarial drug resistance

Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: <a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://www.parasiteswithoutborders.com/">Daniel Griffin</a>, and Christina Naula Guest: Michelle Labrunda Subscribe (free): <a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz">Google Podcasts</a>, <a href= "http://twip.microbeworld.libsynpro.com/rss">RSS</a>, <a href= "http://eepurl.com/Gcw59">email</a> Links for this episode <ul class="wp-block-list"> <li>Join the MicrobeTV <a title="" href= "https://discord.gg/vmnCyBPQds">Discord server</a></li> <li><a title="" href= "https://www.microbe.tv/twip/twip-255-letters/">Letters read</a> on TWiP 255</li> </ul> New Case A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which serves as a terminal complement inhibitor, comes in with left arm swelling. He lives in a city in the north part of the island of Borneo. He is being managed by a doctor in the Malaysian City of Kuching. Now the doctor caring for this man is married to an Infectious Disease expert and she raises concerns that this might be due to a parasitic disease. She is told by the husband that the disease of which she is thinking is not present in the region. She is not swayed and admits him for nightly blood smears which are negative. She then does a rapid immunochromatographic dipstick test that is positive. He lives in a community outside the city and they go to that village and find others with limb swelling issues who are also positive on antigen testing. He is treated with an antibiotic, not antiparasitic for 4 weeks and the arm improves.  Hint: this is not Wuchereria Bancrofti. Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiP  Send your questions and comments to <a href= "mailto:twip@microbe.tv">twip@microbe.tv</a> Music by <a href="http://www.ronaldjenkees.com/">Ronald Jenkees</a>

<description>&lt;p&gt;Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve.&lt;/p&gt; &lt;p&gt;Hosts: &lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;&lt;strong&gt;Vincent Racaniello&lt;/strong&gt;&lt;/a&gt;, &lt;a title="" href= "http://www.parasiteswithoutborders.com/"&gt;&lt;strong&gt;Daniel Griffin&lt;/strong&gt;&lt;/a&gt;, and Christina Naula&lt;/p&gt; &lt;p&gt;Guest: Michelle Labrunda&lt;/p&gt; &lt;p&gt;Subscribe (free): &lt;a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495"&gt;Apple Podcasts&lt;/a&gt;, &lt;a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz"&gt;Google Podcasts&lt;/a&gt;, &lt;a href= "http://twip.microbeworld.libsynpro.com/rss"&gt;RSS&lt;/a&gt;, &lt;a href= "http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;&lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;Join the MicrobeTV &lt;a title="" href= "https://discord.gg/vmnCyBPQds"&gt;Discord server&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.microbe.tv/twip/twip-255-letters/"&gt;Letters read&lt;/a&gt; on TWiP 255&lt;/li&gt; &lt;/ul&gt; &lt;h3 class="wp-block-heading"&gt;New Case&lt;/h3&gt; &lt;p&gt;A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which serves as a terminal complement inhibitor, comes in with left arm swelling. He lives in a city in the north part of the island of Borneo. He is being managed by a doctor in the Malaysian City of Kuching. Now the doctor caring for this man is married to an Infectious Disease expert and she raises concerns that this might be due to a parasitic disease. She is told by the husband that the disease of which she is thinking is not present in the region. She is not swayed and admits him for nightly blood smears which are negative. She then does a rapid immunochromatographic dipstick test that is positive. He lives in a community outside the city and they go to that village and find others with limb swelling issues who are also positive on antigen testing. He is treated with an antibiotic, not antiparasitic for 4 weeks and the arm improves.  Hint: this is not &lt;em&gt;Wuchereria Bancrofti&lt;/em&gt;.&lt;/p&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiP &lt;/p&gt; &lt;p&gt;Send your questions and comments to &lt;a href= "mailto:twip@microbe.tv"&gt;twip@microbe.tv&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Music by &lt;a href="http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt;</description>

Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: , , and Christina Naula Guest: Michelle Labrunda Subscribe (free): , , , ...

TWiP 255: Katayama fever

TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: <a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://www.parasiteswithoutborders.com/">Daniel Griffin</a>, and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): <a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz">Google Podcasts</a>, <a href= "http://twip.microbeworld.libsynpro.com/rss">RSS</a>, <a href= "http://eepurl.com/Gcw59">email</a> Links for this episode <ul class="wp-block-list"> <li>Join the MicrobeTV <a title="" href= "https://discord.gg/vmnCyBPQds">Discord server</a></li> <li>Tissue spaces are reservoirs of <a title="" href= "https://www.nature.com/articles/s41586-024-08151-z">antigenic diversity for T. brucei</a> (Nature)</li> <li>Understanding trypanosome <a title="" href= "https://portlandpress.com/emergtoplifesci/article/1/6/585/11575/Emerging-challenges-in-understanding-trypanosome">antigenic variation</a> (Emerg Top Life Sci)</li> <li><a title="" href= "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009866"> Tissue resident</a> T. brucei (PLoS Path)</li> <li>Hero – <a title="" href= "http://www.trichinella.org/">Dickson Despommier</a></li> <li><a title="" href= "http://www.despommierphotoart.com/index.html">Despommier Photo Art</a></li> <li><a title="" href= "https://www.youtube.com/playlist?list=PLEHrkt_63aeOim8zwQY19xi9r8pG_zHbU"> Parasitology</a> Course (YouTube)</li> </ul> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiP  Send your questions and comments to <a href= "mailto:twip@microbe.tv">twip@microbe.tv</a> Music by <a href="http://www.ronaldjenkees.com/">Ronald Jenkees</a> TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: <a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://www.parasiteswithoutborders.com/">Daniel Griffin</a>, and Christina Naula Subscribe (free): <a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz">Google Podcasts</a>, <a href= "http://twip.microbeworld.libsynpro.com/rss">RSS</a>, <a href= "http://eepurl.com/Gcw59">email</a> Links for this episode <ul class="wp-block-list"> <li>Join the MicrobeTV <a title="" href= "https://discord.gg/vmnCyBPQds">Discord server</a></li> <li>Tissue spaces are reservoirs of <a title="" href= "https://www.nature.com/articles/s41586-024-08151-z">antigenic diversity for T. brucei</a> (Nature)</li> <li>Understanding trypanosome <a title="" href= "https://portlandpress.com/emergtoplifesci/article/1/6/585/11575/Emerging-challenges-in-understanding-trypanosome">antigenic variation</a> (Emerg Top Life Sci)</li> <li><a title="" href= "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009866"> Tissue resident</a> T. brucei (PLoS Path)</li> <li>Hero – <a title="" href= "http://www.trichinella.org/">Dickson Despommier</a></li> <li><a title="" href= "http://www.despommierphotoart.com/index.html">Despommier Photo Art</a></li> <li><a title="" href= "https://www.youtube.com/playlist?list=PLEHrkt_63aeOim8zwQY19xi9r8pG_zHbU"> Parasitology</a> Course (YouTube)</li> </ul> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiP  Send your questions and comments to <a href= "mailto:twip@microbe.tv">twip@microbe.tv</a> Music by <a href="http://www.ronaldjenkees.com/">Ronald Jenkees</a>

<description>&lt;div class="entry-content"&gt; &lt;p&gt;TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier.&lt;/p&gt; &lt;div class="fluid-width-video-wrapper"&gt;&lt;iframe id="fitvid482276" title="YouTube video player" src= "https://www.youtube.com/embed/kXCqw6M0qUo?si=zZ53_QLlkuku1zET" frameborder="0" allow= "accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen="allowfullscreen" name= "fitvid482276"&gt;&lt;/iframe&gt;&lt;/div&gt; &lt;p&gt;Hosts: &lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;&lt;strong&gt;Vincent Racaniello&lt;/strong&gt;&lt;/a&gt;, &lt;a title="" href= "http://www.parasiteswithoutborders.com/"&gt;&lt;strong&gt;Daniel Griffin&lt;/strong&gt;&lt;/a&gt;, and Christina Naula&lt;/p&gt; &lt;figure&gt;&lt;iframe src= "https://html5-player.libsyn.com/embed/episode/id/35224875/height/90/theme/custom/autoplay/no/autonext/no/thumbnail/yes/preload/no/no_addthis/no/direction/backward/render-playlist/no/custom-color/166899/" width="100%" height="90" allowfullscreen= "allowfullscreen"&gt;&lt;/iframe&gt;&lt;/figure&gt; &lt;p&gt;Click arrow to play&lt;br /&gt; Download TWiP #254 (88 MB .mp3, 61 minutes)&lt;/p&gt; &lt;p&gt;Subscribe (free): &lt;a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495"&gt;Apple Podcasts&lt;/a&gt;, &lt;a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz"&gt;Google Podcasts&lt;/a&gt;, &lt;a href= "http://twip.microbeworld.libsynpro.com/rss"&gt;RSS&lt;/a&gt;, &lt;a href= "http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;&lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;Join the MicrobeTV &lt;a title="" href= "https://discord.gg/vmnCyBPQds"&gt;Discord server&lt;/a&gt;&lt;/li&gt; &lt;li&gt;Tissue spaces are reservoirs of &lt;a title="" href= "https://www.nature.com/articles/s41586-024-08151-z"&gt;antigenic diversity for &lt;em&gt;T. brucei&lt;/em&gt;&lt;/a&gt; (Nature)&lt;/li&gt; &lt;li&gt;Understanding trypanosome &lt;a title="" href= "https://portlandpress.com/emergtoplifesci/article/1/6/585/11575/Emerging-challenges-in-understanding-trypanosome"&gt;antigenic variation&lt;/a&gt; (Emerg Top Life Sci)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009866"&gt; Tissue resident&lt;/a&gt; &lt;em&gt;T. brucei&lt;/em&gt; (PLoS Path)&lt;/li&gt; &lt;li&gt;Hero – &lt;a title="" href= "http://www.trichinella.org/"&gt;Dickson Despommier&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "http://www.despommierphotoart.com/index.html"&gt;Despommier Photo Art&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.youtube.com/playlist?list=PLEHrkt_63aeOim8zwQY19xi9r8pG_zHbU"&gt; Parasitology&lt;/a&gt; Course (YouTube)&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiP &lt;/p&gt; &lt;p&gt;Send your questions and comments to &lt;a href= "mailto:twip@microbe.tv"&gt;twip@microbe.tv&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Music by &lt;a href="http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt; &lt;div class="entry-content"&gt; &lt;p&gt;TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier.&lt;/p&gt; &lt;p&gt;Hosts: &lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;&lt;strong&gt;Vincent Racaniello&lt;/strong&gt;&lt;/a&gt;, &lt;a title="" href= "http://www.parasiteswithoutborders.com/"&gt;&lt;strong&gt;Daniel Griffin&lt;/strong&gt;&lt;/a&gt;, and Christina Naula&lt;/p&gt; &lt;p&gt;Subscribe (free): &lt;a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495"&gt;Apple Podcasts&lt;/a&gt;, &lt;a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz"&gt;Google Podcasts&lt;/a&gt;, &lt;a href= "http://twip.microbeworld.libsynpro.com/rss"&gt;RSS&lt;/a&gt;, &lt;a href= "http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;&lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;Join the MicrobeTV &lt;a title="" href= "https://discord.gg/vmnCyBPQds"&gt;Discord server&lt;/a&gt;&lt;/li&gt; &lt;li&gt;Tissue spaces are reservoirs of &lt;a title="" href= "https://www.nature.com/articles/s41586-024-08151-z"&gt;antigenic diversity for &lt;em&gt;T. brucei&lt;/em&gt;&lt;/a&gt; (Nature)&lt;/li&gt; &lt;li&gt;Understanding trypanosome &lt;a title="" href= "https://portlandpress.com/emergtoplifesci/article/1/6/585/11575/Emerging-challenges-in-understanding-trypanosome"&gt;antigenic variation&lt;/a&gt; (Emerg Top Life Sci)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009866"&gt; Tissue resident&lt;/a&gt; &lt;em&gt;T. brucei&lt;/em&gt; (PLoS Path)&lt;/li&gt; &lt;li&gt;Hero – &lt;a title="" href= "http://www.trichinella.org/"&gt;Dickson Despommier&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "http://www.despommierphotoart.com/index.html"&gt;Despommier Photo Art&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.youtube.com/playlist?list=PLEHrkt_63aeOim8zwQY19xi9r8pG_zHbU"&gt; Parasitology&lt;/a&gt; Course (YouTube)&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiP &lt;/p&gt; &lt;p&gt;Send your questions and comments to &lt;a href= "mailto:twip@microbe.tv"&gt;twip@microbe.tv&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Music by &lt;a href="http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt; &lt;/div&gt; &lt;/div&gt;</description>

TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier.  Hosts: , , and Christina Naula  Click arrow to play...

TWiP 254: Our hero Dickson

TWiP solves the case of the man with somnolence and something extra-erythrocytic, and presents a new puzzle for you to solve. Hosts: <a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://www.parasiteswithoutborders.com/">Daniel Griffin</a>, and Christina Naula Subscribe (free): <a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz">Google Podcasts</a>, <a href= "http://twip.microbeworld.libsynpro.com/rss">RSS</a>, <a href= "http://eepurl.com/Gcw59">email</a> Links for this episode <ul class="wp-block-list"> <li>Join the MicrobeTV <a title="" href= "https://discord.gg/vmnCyBPQds">Discord server</a></li> <li><a title="" href= "https://www.microbe.tv/twip/twip-253-letters/">Letters read</a> on TWiP 253</li> </ul> New Case 26-year-old female with no past medical history.  Patient is from Georgia in the US and is volunteering in Hérico, Guinea (town in the Lélouma Prefecture in the Labé Region of northern-central Guinea). She arrived in Guinea in December  2023.  She was taking doxycycline for malaria prophylaxis and says that she has not missed any doses On October  2024 she presented with fever and dry cough.  Lab work was done and follow up planned for the following day.  The patient slept poorly, was febrile to 104 and had ongoing cough.  The next day she went to the hospital and was evaluated in the ER for acute febrile illness of unclear etiology.   In the hospital, VS were 97.9F, BP 105/70, P 94 Oxy sat 98%, normal physical exam. She was started on Augmentin and Coartem. Pause here to think about the differential at this point and maybe some more history and what testing you might want WBC 14, Hb 13, HCT 40, PLT 285, Neut abs 8, Eos Abso0.80; BUN/creat  normal, AST normal; ALT 44, GGT 125 Stool parasite screen + for some sort of eggs, malaria smear negative, CXR with b/l infiltrates She was given a medication (vomited 30 min after dose received).  She then received a second dose of medication 5 hours after the first) and was discharged. The following day the patient returned to the ER, stating that she felt worse.  Her temperature had climbed to 104 overnight, and she developed watery diarrhea and nausea.  There were no additional episodes of vomiting.  She was given an additional dose of a medication, ibuprofen, and started on ceftriaxone 1 gm IV Q12 hrs.  During the day she continued to have low grade fevers and developed abdominal pain.  That night she was again febrile to 104 F.    She remained admitted for 5 days with ongoing symptoms of diarrhea, nighttime fevers and diffuse abdominal discomfort.  Three more malaria tests were negative (rapid test and slide review) Blood cultures collected – no growth She continued to have mild elevation of WBC and slight elevation of AST and ALT. The patient was transferred to a different hospital. They give her a different medication, and within 24 hours symptoms resolve.  What is the diagnosis and what happened here with management? Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiP  Send your questions and comments to <a href= "mailto:twip@microbe.tv">twip@microbe.tv</a> Music by <a href="http://www.ronaldjenkees.com/">Ronald Jenkees</a>

<description>&lt;p&gt;TWiP solves the case of the man with somnolence and something extra-erythrocytic, and presents a new puzzle for you to solve.&lt;/p&gt; &lt;p&gt;Hosts: &lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;&lt;strong&gt;Vincent Racaniello&lt;/strong&gt;&lt;/a&gt;, &lt;a title="" href= "http://www.parasiteswithoutborders.com/"&gt;&lt;strong&gt;Daniel Griffin&lt;/strong&gt;&lt;/a&gt;, and Christina Naula&lt;/p&gt; &lt;p&gt;Subscribe (free): &lt;a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495"&gt;Apple Podcasts&lt;/a&gt;, &lt;a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz"&gt;Google Podcasts&lt;/a&gt;, &lt;a href= "http://twip.microbeworld.libsynpro.com/rss"&gt;RSS&lt;/a&gt;, &lt;a href= "http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;&lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;Join the MicrobeTV &lt;a title="" href= "https://discord.gg/vmnCyBPQds"&gt;Discord server&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.microbe.tv/twip/twip-253-letters/"&gt;Letters read&lt;/a&gt; on TWiP 253&lt;/li&gt; &lt;/ul&gt; &lt;h3 class="wp-block-heading"&gt;New Case&lt;/h3&gt; &lt;p&gt;26-year-old female with no past medical history.  Patient is from Georgia in the US and is volunteering in Hérico, Guinea (town in the Lélouma Prefecture in the Labé Region of northern-central Guinea). She arrived in Guinea in December  2023.  She was taking doxycycline for malaria prophylaxis and says that she has not missed any doses&lt;/p&gt; &lt;p&gt;On October  2024 she presented with fever and dry cough.  Lab work was done and follow up planned for the following day.  The patient slept poorly, was febrile to 104 and had ongoing cough.  The next day she went to the hospital and was evaluated in the ER for acute febrile illness of unclear etiology.  &lt;/p&gt; &lt;p&gt;In the hospital, VS were 97.9F, BP 105/70, P 94 Oxy sat 98%, normal physical exam.&lt;/p&gt; &lt;p&gt;She was started on Augmentin and Coartem.&lt;/p&gt; &lt;p&gt;&lt;em&gt;Pause here to think about the differential at this point and maybe some more history and what testing you might want&lt;/em&gt;&lt;/p&gt; &lt;p&gt;WBC 14, Hb 13, HCT 40, PLT 285, Neut abs 8, Eos Abso0.80; BUN/creat  normal, AST normal; ALT 44, GGT 125&lt;/p&gt; &lt;p&gt;Stool parasite screen + for some sort of eggs, malaria smear negative, CXR with b/l infiltrates&lt;/p&gt; &lt;p&gt;She was given a medication (vomited 30 min after dose received).  She then received a second dose of medication 5 hours after the first) and was discharged. The following day the patient returned to the ER, stating that she felt worse.  Her temperature had climbed to 104 overnight, and she developed watery diarrhea and nausea.  There were no additional episodes of vomiting.  She was given an additional dose of a medication, ibuprofen, and started on ceftriaxone 1 gm IV Q12 hrs.  During the day she continued to have low grade fevers and developed abdominal pain.  That night she was again febrile to 104 F.   &lt;/p&gt; &lt;p&gt;She remained admitted for 5 days with ongoing symptoms of diarrhea, nighttime fevers and diffuse abdominal discomfort.  Three more malaria tests were negative (rapid test and slide review)&lt;/p&gt; &lt;p&gt;Blood cultures collected – no growth&lt;/p&gt; &lt;p&gt;She continued to have mild elevation of WBC and slight elevation of AST and ALT.&lt;/p&gt; &lt;p&gt;The patient was transferred to a different hospital. They give her a different medication, and within 24 hours symptoms resolve. &lt;/p&gt; &lt;p&gt;What is the diagnosis and what happened here with management?&lt;/p&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiP &lt;/p&gt; &lt;p&gt;Send your questions and comments to &lt;a href= "mailto:twip@microbe.tv"&gt;twip@microbe.tv&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Music by &lt;a href="http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt;</description>

TWiP solves the case of the man with somnolence and something extra-erythrocytic, and presents a new puzzle for you to solve. Hosts: , , and Christina Naula Subscribe (free): , , ,  Links for this episode  Join the...

TWiP 253: Sub-Saharan somnolence

TWiP discusses a study of the safety and immunogenicity of a late liver-stage attenuated malaria parasite delivered by mosquito bite. Hosts: <a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a title="" href= "http://www.parasiteswithoutborders.com/">Daniel Griffin</a>, and Christina Naula Subscribe (free): <a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz">Google Podcasts</a>, <a href= "http://twip.microbeworld.libsynpro.com/rss">RSS</a>, <a href= "http://eepurl.com/Gcw59">email</a> Links for this episode <ul class="wp-block-list"> <li>Join the MicrobeTV <a title="" href= "https://discord.gg/vmnCyBPQds">Discord server</a></li> <li>Live attenuated <a title="" href= "https://www.nejm.org/doi/full/10.1056/NEJMoa2313892?mtm_source=25">malaria vaccine</a> (NEJM)</li> <li><a title="" href= "https://www.cell.com/trends/parasitology/fulltext/S1471-4922(23)00074-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471492223000740%3Fshowall%3Dtrue"> Plasmodium metabolism</a> during hepatic development (Cell)</li> <li>Heroes – <a title="" href= "https://en.wikipedia.org/wiki/Jimmy_Carter">Jimmy and Rosallyn Carter</a>, and the Carter Center</li> <li>The Carter Center <a title="" href= "https://www.cartercenter.org/health/guinea_worm/index.html">Guinea Worm Eradication Programme</a></li> <li><a title="" href= "https://ourworldindata.org/guinea-worm-path-eradication">Guinea Worm data visualisations</a> (Our World in Data)</li> </ul> Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiP  Send your questions and comments to <a href= "mailto:twip@microbe.tv">twip@microbe.tv</a> Music by <a href="http://www.ronaldjenkees.com/">Ronald Jenkees</a>

<description>&lt;p&gt;TWiP discusses a study of the safety and immunogenicity of a late liver-stage attenuated malaria parasite delivered by mosquito bite.&lt;/p&gt; &lt;p&gt;Hosts: &lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;&lt;strong&gt;Vincent Racaniello&lt;/strong&gt;&lt;/a&gt;, &lt;a title="" href= "http://www.parasiteswithoutborders.com/"&gt;&lt;strong&gt;Daniel Griffin&lt;/strong&gt;&lt;/a&gt;, and Christina Naula&lt;/p&gt; &lt;p&gt;Subscribe (free): &lt;a href= "https://podcasts.apple.com/us/podcast/this-week-in-parasitism/id340512495"&gt;Apple Podcasts&lt;/a&gt;, &lt;a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXAubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz"&gt;Google Podcasts&lt;/a&gt;, &lt;a href= "http://twip.microbeworld.libsynpro.com/rss"&gt;RSS&lt;/a&gt;, &lt;a href= "http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;&lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;Join the MicrobeTV &lt;a title="" href= "https://discord.gg/vmnCyBPQds"&gt;Discord server&lt;/a&gt;&lt;/li&gt; &lt;li&gt;Live attenuated &lt;a title="" href= "https://www.nejm.org/doi/full/10.1056/NEJMoa2313892?mtm_source=25"&gt;malaria vaccine&lt;/a&gt; (NEJM)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.cell.com/trends/parasitology/fulltext/S1471-4922(23)00074-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471492223000740%3Fshowall%3Dtrue"&gt; &lt;em&gt;Plasmodium&lt;/em&gt; metabolism&lt;/a&gt; during hepatic development (Cell)&lt;/li&gt; &lt;li&gt;Heroes – &lt;a title="" href= "https://en.wikipedia.org/wiki/Jimmy_Carter"&gt;Jimmy and Rosallyn Carter&lt;/a&gt;, and the Carter Center&lt;/li&gt; &lt;li&gt;The Carter Center &lt;a title="" href= "https://www.cartercenter.org/health/guinea_worm/index.html"&gt;Guinea Worm Eradication Programme&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://ourworldindata.org/guinea-worm-path-eradication"&gt;Guinea Worm data visualisations&lt;/a&gt; (Our World in Data)&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiP &lt;/p&gt; &lt;p&gt;Send your questions and comments to &lt;a href= "mailto:twip@microbe.tv"&gt;twip@microbe.tv&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Music by &lt;a href="http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt;</description>

TWiP discusses a study of the safety and immunogenicity of a late liver-stage attenuated malaria parasite delivered by mosquito bite. Hosts: , , and Christina Naula Subscribe (free): , , ,  Links for this episode  Join...

TWiP 252: For malaria vaccine, mosquito is the needle

TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.

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