<description>&lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; TWiM explores two different ways that bacteria defend against phages through the synthesis of cyclic nucleotides.&lt;br /&gt; &lt;br /&gt;&lt;/span&gt;&lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; &lt;strong id= "docs-internal-guid-f2b95bdb-7fff-fd6c-b053-683d94122a86"&gt;Hosts:  &lt;a href= "https://education.musc.edu/MUSCApps/facultydirectory/Schmidt-Michael"&gt; Michael Schmidt&lt;/a&gt; and &lt;a href= "https://www.pugetsound.edu/directory/mark-martin"&gt;Mark O. Martin&lt;/a&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"&gt;  &lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Become a&lt;/span&gt; &lt;a style="text-decoration: none;" href= "http://www.microbe.tv/contribute"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; patron&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; of TWiM.&lt;br /&gt; &lt;br /&gt;&lt;/span&gt;&lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin: 0pt 5pt 0pt 1pt; text-indent: -4pt; padding: 0pt 0pt 0pt 4pt;"&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Links for this episode:&lt;br /&gt;&lt;/span&gt;&lt;/p&gt; &lt;ul style= "margin-top: 0px; margin-bottom: 0px; padding-inline-start: 48px;"&gt; &lt;li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;" role="presentation"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Decoy cyclic nucleotides in&lt;/span&gt; &lt;a style= "text-decoration: none;" href= "https://www.nature.com/articles/s41586-025-09557-z"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; phage defense&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; (Nature)&lt;/span&gt;&lt;/p&gt; &lt;/li&gt; &lt;li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;" role="presentation"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; CRISPR defense with&lt;/span&gt; &lt;a style="text-decoration: none;" href= "https://www.nature.com/articles/s41586-025-09569-9"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; nucleotides&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; (Nature)&lt;/span&gt;&lt;/p&gt; &lt;/li&gt; &lt;li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;" role="presentation"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; A decoy defence molecule to set&lt;/span&gt; &lt;a style= "text-decoration: none;" href= "https://pubmed.ncbi.nlm.nih.gov/41034659/"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; a trap for viruses&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; (Nature)&lt;/span&gt;&lt;/p&gt; &lt;/li&gt; &lt;li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;" role="presentation"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Cyclic oligonucleotide-based antiphage signaling system immunity (Curr Opin Immunol)&lt;br /&gt;&lt;/span&gt;&lt;/p&gt; &lt;/li&gt; &lt;/ul&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-top: 0pt; margin-bottom: 8pt;"&gt;  &lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-top: 0pt; margin-bottom: 8pt;"&gt; &lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Music used on TWiM is composed and performed by&lt;/span&gt; &lt;a style= "text-decoration: none;" href= "http://ronaldjenkees.com/"&gt;&lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #18689a; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Ronald Jenkees&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; and used with permission.&lt;/span&gt;&lt;/p&gt; &lt;p&gt;&lt;strong id= "docs-internal-guid-d3210c32-7fff-c5e7-6cbf-299011809937" style= "caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; font-weight: normal;"&gt; &lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Send your microbiology questions and comments to&lt;/span&gt; &lt;span style="font-size: 13.5pt; font-family: Arial, sans-serif; color: #18689a; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; twim@microbe.tv&lt;/span&gt;&lt;/strong&gt;&lt;/p&gt;</description>

This Week in Microbiology

Vincent Racaniello

343: Nucleotides to the Defense

OCT 25, 202543 MIN
This Week in Microbiology

343: Nucleotides to the Defense

OCT 25, 202543 MIN

Description

TWiM explores two different ways that bacteria defend against phages through the synthesis of cyclic nucleotides.

Hosts: Michael Schmidt and Mark O. Martin

Become a patron of TWiM.

Links for this episode:

  • Decoy cyclic nucleotides in phage defense (Nature)

  • CRISPR defense with nucleotides (Nature)

  • A decoy defence molecule to set a trap for viruses (Nature)

  • Cyclic oligonucleotide-based antiphage signaling system immunity (Curr Opin Immunol)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to [email protected]