<description>&lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; TWiM explains how competition for nutrients anticipates and potentially mitigate drug side effects on the gut microbiota, and metabolic control of porin permeability influences antibiotic resistance.&lt;br /&gt; &lt;br /&gt;&lt;/span&gt;&lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Become a&lt;/span&gt; &lt;a style="text-decoration: none;" href= "http://www.microbe.tv/contribute"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; patron&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; of TWiM.&lt;/span&gt;&lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin: 0pt 5pt 0pt 1pt; text-indent: -4pt; padding: 0pt 0pt 0pt 4pt;"&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; &lt;br /&gt; Links for this episode:&lt;/span&gt;&lt;/p&gt; &lt;ul style= "margin-top: 0px; margin-bottom: 0px; padding-inline-start: 48px;"&gt; &lt;li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;" role="presentation"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Nutrient competition predicts&lt;/span&gt; &lt;a style= "text-decoration: none;" href= "https://www.cell.com/cell/abstract/S0092-8674(25)01243-7"&gt;&lt;span style="font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; drug effects on microbiota&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; (Cell)&lt;/span&gt;&lt;/p&gt; &lt;/li&gt; &lt;li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;" role="presentation"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Metabolic control of&lt;/span&gt; &lt;a style="text-decoration: none;" href= "https://www.nature.com/articles/s41564-025-02175-5"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; porin permeability&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; influences antibiotic resistance in&lt;/span&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: italic; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; E coli&lt;/span&gt; &lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; (Nat Micro)&lt;/span&gt;&lt;/p&gt; &lt;/li&gt; &lt;li dir="ltr" style= "list-style-type: disc; font-size: 12pt; font-family: Arial, sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre;" aria-level="1"&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;" role="presentation"&gt;&lt;a style="text-decoration: none;" href= "https://phisanti.github.io/"&gt;&lt;span style= "font-size: 12pt; font-family: Arial, sans-serif; color: #1155cc; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: underline; text-decoration-skip-ink: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Santiago Cano-Muniz&lt;/span&gt;&lt;/a&gt;&lt;/p&gt; &lt;/li&gt; &lt;/ul&gt; &lt;p style= "list-style-type: disc;font-size: 12pt;font-family: Arial, sans-serif;color: rgb(0, 0, 0);background-color: transparent;font-weight: 400;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-alternates: normal;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-position: normal;font-variant-emoji: normal;text-decoration-color: currentcolor;text-decoration-line: none;text-decoration-style: solid;text-decoration-thickness: auto;vertical-align: baseline;text-wrap-mode: nowrap;white-space-collapse: preserve;"&gt;  &lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-top: 0pt; margin-bottom: 8pt;"&gt; &lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Music used on TWiM is composed and performed by&lt;/span&gt; &lt;a style= "text-decoration: none;" href= "http://ronaldjenkees.com/"&gt;&lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #18689a; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Ronald Jenkees&lt;/span&gt;&lt;/a&gt; &lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; and used with permission.&lt;/span&gt;&lt;/p&gt; &lt;p dir="ltr" style= "line-height: 1.38; margin-top: 0pt; margin-bottom: 8pt;"&gt; &lt;span style= "font-size: 13.5pt; font-family: Arial, sans-serif; color: #000000; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; Send your microbiology questions and comments to&lt;/span&gt; &lt;span style="font-size: 13.5pt; font-family: Arial, sans-serif; color: #18689a; background-color: #ffffff; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-alternates: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"&gt; twim@microbe.tv&lt;/span&gt;&lt;/p&gt; &lt;p&gt; &lt;/p&gt;</description>

This Week in Microbiology

Vincent Racaniello

346: Metabolism and Porin Permeability

DEC 13, 202553 MIN
This Week in Microbiology

346: Metabolism and Porin Permeability

DEC 13, 202553 MIN

Description

TWiM explains how competition for nutrients anticipates and potentially mitigate drug side effects on the gut microbiota, and metabolic control of porin permeability influences antibiotic resistance. Become a patron of TWiM. Links for this episode: Nutrient competition predicts drug effects on microbiota (Cell) Metabolic control of porin permeability influences antibiotic resistance in E coli (Nat Micro) Santiago Cano-Muniz Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to [email protected]