The Human Upgrade: Biohacking for Longevity & Performance

The edges of medicine are moving faster than the mainstream — from an engineered virus stopping pancreatic cancer to a diabetes drug cutting breast cancer risk to 21 years of Finnish data finally settling the sauna debate — and your job is to catch the signal before it becomes a headline.

In this episode, Dave Asprey and the founders of Mara Labs discuss how sulforaphane (in their BroccoLite supplement) activates all three detox pathways to help the body excrete microplastics, heavy metals, BPA, and other environmental toxins, while also covering its benefits for brain health, hormone balance, autism, and longevity.

Host Dave Asprey interviews Justin Kirkland of Amino Innovations and Precision Peptide Company, a chemist with 30 years of experience, about how peptides are synthesized, sourced safely in the US, and delivered through injections, microneedle patches, and nasal sprays, while discussing quality control issues in the gray market, which peptides are most promising or overhyped, and how genetics and gut bacteria influence individual responses.

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet. In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness. Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 00:00 – Personal Experience 00:47 – Root Cause: Not in Your Head 01:05 – Blood Flow and Brain Function 02:10 – The Calf Pump 03:52 – Foot Sensory Signals 04:26 – Nervous System Impact 06:22 – How to Fix It 07:51 – Personal Results Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5:29 PMClaude responded: This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control…This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control the pace of aging, new evidence linking depression to immune biology, and a genetics paper that says half your lifespan was loaded before you were born.