CHEST December 2025, Volume 168, Issue 6       CHEST® journal's Editor in Chief Peter Mazzone, MD, MPH, FCCP, highlights key research published in the journal CHEST December 2025 issue, including an exploration of the relationship between inflammation and mucociliary clearance in chronic respiratory conditions, an investigation into the association of hypoxic burden with major cardiovascular events, and more.       Moderator:    Peter Mazzone, MD, MPH, FCCP