Open Notebook Science - Falcipain-2 Preliminary Results
AUG 22, 2008-1 MIN
Open Notebook Science - Falcipain-2 Preliminary Results
AUG 22, 2008-1 MIN
Description
This talk was presented by Jean-Claude Bradley at the American Chemical Society meeting in Philadelphia on August 20, 2008. An introduction to <a href="http://drexel-coas-elearning.blogspot.com/2006/09/open-notebook-science.html">Open Notebook Science</a> is presented followed by an illustration of how ONS can be used in drug discovery. New data relating to the anti-malarial activity of Ugi products on <a href="http://usefulchem.wikispaces.com/D-EXP014">2 falcipain-2 docking sites</a> is detailed. The docking calculations were provided by <a href="http://www.informatics.indiana.edu/people/profiles.asp?u=rguha">Rajarshi Guha</a> and the enzyme and in vitro assays on Plasmodium falciparum were provided by <a href="http://knol.google.com/k/philip-rosenthal/malaria/dtqBgoqt/MRpmSg?locale=en#">Phil Rosenthal</a> and Jiri Gut. Most of the syntheses were carried out by Khalid Mirza in the Bradley group.<br /><a href="http://showme.physics.drexel.edu/bradley/OpenNotebookScienceACSFA08.mp3">audio (mp3)</a><br /><a href="http://video.google.com/videoplay?docid=3251406956070376532&hl=en">Google Video screencast</a><br /><div style="width: 425px; text-align: left;" id="__ss_565591"><a style="margin: 12px 0pt 3px; font-family: Helvetica,Arial,Sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 14px; line-height: normal; font-size-adjust: none; font-stretch: normal; display: block; text-decoration: underline;" href="http://www.slideshare.net/jcbradley/open-notebook-science-and-preliminary-falcipain2-results-presentation?src=embed" title="Open Notebook Science and Preliminary Falcipain-2 Results">Open Notebook Science and Preliminary Falcipain-2 Results</a><object style="margin: 0px;" height="355" width="425"><param name="movie" value="http://static.slideshare.net/swf/ssplayer2.swf?doc=bradleyacsphillyons08-1219426370693530-8&stripped_title=open-notebook-science-and-preliminary-falcipain2-results-presentation"><param name="allowFullScreen" value="true"><param name="allowScriptAccess" value="always"><embed src="http://static.slideshare.net/swf/ssplayer2.swf?doc=bradleyacsphillyons08-1219426370693530-8&stripped_title=open-notebook-science-and-preliminary-falcipain2-results-presentation" type="application/x-shockwave-flash" allowscriptaccess="always" allowfullscreen="true" height="355" width="425"></embed></object><div style="font-size: 11px; font-family: tahoma,arial; height: 26px; padding-top: 2px;">View SlideShare <a style="text-decoration: underline;" href="http://www.slideshare.net/jcbradley/open-notebook-science-and-preliminary-falcipain2-results-presentation?src=embed" title="View Open Notebook Science and Preliminary Falcipain-2 Results on SlideShare">presentation</a> or <a style="text-decoration: underline;" href="http://www.slideshare.net/upload?src=embed">Upload</a> your own. (tags: <a style="text-decoration: underline;" href="http://slideshare.net/tag/reaction">reaction</a> <a style="text-decoration: underline;" href="http://slideshare.net/tag/ugi">ugi</a>)</div></div><br /><a href="http://video.google.com/videoplay?docid=3251406956070376532&hl=en"></a><br /><br /><br /><div style="margin-top: 10px; height: 15px;" class="zemanta-pixie"><a class="zemanta-pixie-a" href="http://reblog.zemanta.com/zemified/ef43e167-ec82-4136-9fbe-d4e9431f7a40/" title="Zemified by Zemanta"><img style="border: medium none ; float: right;" class="zemanta-pixie-img" src="http://img.zemanta.com/reblog_e.png?x-id=ef43e167-ec82-4136-9fbe-d4e9431f7a40" alt="Reblog this post [with Zemanta]" /></a></div>
![<description>This talk was presented by Jean-Claude Bradley at the American Chemical Society meeting in Philadelphia on August 20, 2008. An introduction to <a href="http://drexel-coas-elearning.blogspot.com/2006/09/open-notebook-science.html">Open Notebook Science</a> is presented followed by an illustration of how ONS can be used in drug discovery. New data relating to the anti-malarial activity of Ugi products on <a href="http://usefulchem.wikispaces.com/D-EXP014">2 falcipain-2 docking sites</a> is detailed. The docking calculations were provided by <a href="http://www.informatics.indiana.edu/people/profiles.asp?u=rguha">Rajarshi Guha</a> and the enzyme and in vitro assays on Plasmodium falciparum were provided by <a href="http://knol.google.com/k/philip-rosenthal/malaria/dtqBgoqt/MRpmSg?locale=en#">Phil Rosenthal</a> and Jiri Gut. Most of the syntheses were carried out by Khalid Mirza in the Bradley group.<br /><a href="http://showme.physics.drexel.edu/bradley/OpenNotebookScienceACSFA08.mp3">audio (mp3)</a><br /><a href="http://video.google.com/videoplay?docid=3251406956070376532&amp;hl=en">Google Video screencast</a><br /><div style="width: 425px; text-align: left;" id="__ss_565591"><a style="margin: 12px 0pt 3px; font-family: Helvetica,Arial,Sans-serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 14px; line-height: normal; font-size-adjust: none; font-stretch: normal; display: block; text-decoration: underline;" href="http://www.slideshare.net/jcbradley/open-notebook-science-and-preliminary-falcipain2-results-presentation?src=embed" title="Open Notebook Science and Preliminary Falcipain-2 Results">Open Notebook Science and Preliminary Falcipain-2 Results</a><object style="margin: 0px;" height="355" width="425"><param name="movie" value="http://static.slideshare.net/swf/ssplayer2.swf?doc=bradleyacsphillyons08-1219426370693530-8&amp;stripped_title=open-notebook-science-and-preliminary-falcipain2-results-presentation"><param name="allowFullScreen" value="true"><param name="allowScriptAccess" value="always"><embed src="http://static.slideshare.net/swf/ssplayer2.swf?doc=bradleyacsphillyons08-1219426370693530-8&amp;stripped_title=open-notebook-science-and-preliminary-falcipain2-results-presentation" type="application/x-shockwave-flash" allowscriptaccess="always" allowfullscreen="true" height="355" width="425"></embed></object><div style="font-size: 11px; font-family: tahoma,arial; height: 26px; padding-top: 2px;">View SlideShare <a style="text-decoration: underline;" href="http://www.slideshare.net/jcbradley/open-notebook-science-and-preliminary-falcipain2-results-presentation?src=embed" title="View Open Notebook Science and Preliminary Falcipain-2 Results on SlideShare">presentation</a> or <a style="text-decoration: underline;" href="http://www.slideshare.net/upload?src=embed">Upload</a> your own. (tags: <a style="text-decoration: underline;" href="http://slideshare.net/tag/reaction">reaction</a> <a style="text-decoration: underline;" href="http://slideshare.net/tag/ugi">ugi</a>)</div></div><br /><a href="http://video.google.com/videoplay?docid=3251406956070376532&amp;hl=en"></a><br /><br /><br /><div style="margin-top: 10px; height: 15px;" class="zemanta-pixie"><a class="zemanta-pixie-a" href="http://reblog.zemanta.com/zemified/ef43e167-ec82-4136-9fbe-d4e9431f7a40/" title="Zemified by Zemanta"><img style="border: medium none ; float: right;" class="zemanta-pixie-img" src="http://img.zemanta.com/reblog_e.png?x-id=ef43e167-ec82-4136-9fbe-d4e9431f7a40" alt="Reblog this post [with Zemanta]" /></a></div></description>](https://us-central1-podcastguru-217d6.cloudfunctions.net/gcf_get_image?image_url=http://photos1.blogger.com/img/267/3447/320/headshot.jpg&width=300&height=300&api_key=xqFmUFX5BHLBTA)