Beyond the Buzz: Where GLP-1s Really Fit in PMOS Care

📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. Dr. Komal Patil-Sisodia continues the PMOS Awareness Month series by walking through where GLP-1 medications, like semaglutide and tirzepatide, fit into PMOS treatment. She explains what GLP-1s actually do in the body, who is likely to benefit, who they are not built for, and why they are never a stand-alone treatment plan for PMOS. In This Episode What a GLP-1 is and the three main effects these medications have on the body Why insulin resistance sits at the center of PMOS for so many patients, and how that connects to androgen levels and symptoms like acne and excess hair growth Who is the clearest fit for a GLP-1: patients with insulin resistance or higher body weight, and those who haven't seen enough improvement from metformin or lifestyle changes alone Who GLP-1s are not built for: lean PMOS patients without insulin resistance, and anyone trying to conceive soon Why GLP-1s only work well alongside lifestyle change, and the real risks of low protein and fiber intake while on these medications What a GLP-1 does not replace: ongoing metabolic monitoring, fertility treatment, and androgen-targeted treatments like birth control pills or spironolactone The four questions Dr. Patil-Sisodia asks herself before recommending a GLP-1 for a PMOS patient Timestamps 00:00 Podcast Intro 01:01 Series Setup 02:13 GLP-1 Basics 02:45 Why It Matters 03:28 Who Benefits 04:32 Who Should Avoid 05:27 Lifestyle and Safety 06:15 What GLP-1s Don't Replace 07:40 How I Decide 08:29 Wrap Up and Next Week 09:36 Mini Course Promo Links Mentioned Newsletter sign-up: eastsidemm.com/newsletter Follow Dr. Patil-Sisodia: @drpatilsisodia on Instagram and TikTok Thanks for listening. Find more info about Clearly Hormonal on the website or Instagram.