Cleveland Clinic Cancer Advances

Patients with advanced lung cancer often experience disease progression despite treatment with immune checkpoint inhibitors. In this episode of Cancer Advances, Wen Wee Ma, MBBS, discusses data evaluating inhaled KB707, a modified herpes simplex virus designed to locally deliver IL-2 and IL-12, in combination with pembrolizumab. Dr. Ma reviews the rationale behind this novel immunotherapy approach, early efficacy and safety findings and the potential role of inhaled therapies in future lung c...

Rare cancers and blood diseases present unique diagnostic and treatment challenges, often requiring specialized expertise and multidisciplinary care. In this episode of Cancer Advances, Sudipto Mukherjee, MD, PhD, MPH, discusses how Cleveland Clinic's Rare Cancers and Blood Diseases Program is improving diagnostic accuracy, accelerating access to care and advancing research across more than 90 rare conditions. Learn how integrated pathology review, genomic insights, collaborative care models ...

Hematologist and myeloma specialist Shahzad Raza, MD, joins the Cancer Advances podcast to discuss emerging cellular and immune therapies for AL amyloidosis. Listen as Dr. Raza reviews early data on CAR T-cell therapy and bispecific antibodies, their potential to induce deep hematologic responses and how these approaches may improve organ function and long-term outcomes for patients with this rare plasma cell disorder.

As recommendations for germline genetic testing continue to expand, many eligible patients remain untested. In this episode of Cancer Advances, Demitrios Dedousis, MD, discusses current testing indications, common gaps in implementation and the clinical implications of identifying hereditary cancer predisposition syndromes. Learn how germline findings can influence treatment decisions, screening protocols and risk assessment for families.

Bethany Samuelson Bannow, MD, Director of Classical Hematology at Cleveland Clinic, joins the Cancer Advances podcast to discuss how stronger collaboration between oncologists, primary care physicians and classical hematologists can improve diagnostic efficiency and patient outcomes. Listen as Dr. Samuelson Bannow shares practical referral guidance, highlights new diagnostic care pathways for common blood disorders, and explores strategies to address workforce shortages while expanding access...