ASCRS Guidelines: Appendiceal Neoplasms & Anal Cancer

The newly published 2025 ASCRS guidelines for appendiceal neoplasms represent a total departure from traditional surgical dogma, revealing a 16% risk of concealed malignancy in patients presenting with periappendiceal abscesses. This mandates strict oncologic follow-up after initial antibiotic therapy and percutaneous drainage. Beyond the appendix, this episode explores the etiology, staging, and treatment algorithms for anal squamous cell carcinoma. Driven by HPV (specifically serotypes 16 and 18) within the anal transitional zone (ATZ), anal cancer requires a distinct management approach far different from colorectal adenocarcinoma.