SGLT2i Therapy for Horses

This episode reviews cases of steroid-induced laminitis and examines recent research and owner-reported experiences using SGLT2 inhibitors (most commonly ertugliflozin) as an off-label treatment for equine metabolic syndrome and hyperinsulinemia-associated laminitis. An online survey of 342 owners found most horses treated with SGLT2Is showed improved quality of life and reduced pain, with many horses spared from euthanasia; common initial side effects included increased drinking and urination, weight loss, and dullness, which were often dose-dependent or resolved over time. Key takeaways: SGLT2Is show promise as a rescue option for laminitis when combined with strict dietary management and good hoof care, but long-term safety, availability, cost, and further research remain important considerations. Research https://beva.onlinelibrary.wiley.com/doi/abs/10.1111/eve.14071 https://scholar.google.com/scholar?hl=en&as_sdt=0%2C14&as_vis=1&q=sundra+et+al+2025+Horseowner&btnG=#d=gs_qabs&t=1787417730062&u=%23p%3DSFYkeG9TZt4J Humble Hoof Podcast Episode https://open.spotify.com/episode/4CvEegebGNduL7hNJDAlFc?si=UWRrM3TuRJuXyg0Rxx_vSA&utm_source=copy-link