Rethinking Chronic Endometritis: Why Antibiotics Fail in Recurrent Miscarriage

Send us Fan Mail For years, the standard response to finding CD138 cells in the uterine lining was an aggressive 14-day course of doxycycline, operating on the unproven assumption that an active bacterial infection caused recurrent pregnancy loss. In this episode, we break down the definitive findings from the UK’s landmark SERM trial, which pitted doxycycline against a placebo in over 400 women to reveal a statistical dead heat in live birth rates. The data shows that CD138 fluctuations align with menstrual cycle timing and delayed endometrial maturation rather than infection, proving that routine antibiotic protocols are an ineffective illusion that must be retired in favor of real biological answers.