0.9% Sodium Chloride: The Drug We Give Without Thinking (Free Preview) | Anesthesia Drug Compendium Series

Got something to say to this podcast? Send a voicemail, and you might hear yourself on the next episode! 0.9% Sodium Chloride: The Drug We Give Without Thinking (Free Preview) | Anesthesia Drug Compendium Series Normal" saline is not normal. Plasma runs Na⁺ ≈ 140 and Cl⁻ ≈ 100; the bag holds 154 of each at 308 mOsm/L. The supraphysiological chloride — half again above normal — defines everything modern medicine worries about in the bag. This episode covers: the 1832 cholera outbreak that invented IV fluid resuscitation, Hamburger's 1896 red-cell experiments that gave us the "0.9%" (and overshot the true isotonic value), hyperchloremic metabolic acidosis via the Stewart strong-ion-difference mechanism, the 2018 SMART and SALT-ED trials, and the three jobs no balanced crystalloid does better than normal saline. The full episode, available on Supercast >>> https://diaryofaloststudent.supercast.com/ Timestamps 00:42 — "Normal" is not normal 01:16 — The modern formulation 01:40 — The full episode continues on Supercast... Full Episode The complete saline episode — is on Supercast https://diaryofaloststudent.supercast.com/ If this made something click, leave a 5-star rating and follow the show. That's how other anesthesia providers — residents, SRNAs, SAAs, CRNAs, and anesthesiologists — find it. New episodes every week.