Acetaminophen and Salicylate Toxicity

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity 1:13 — Welcome and topic introduction 3:50 — Key rules: check levels, call Poison Control 5:13 — Acetaminophen pathophysiology 8:16 — Salicylate pathophysiology 10:51 — Coingestions 11:11 — Differential diagnosis 12:19 — History & pre-hospital care 15:28 — Product confusion 17:08 — Toxic dose thresholds 18:26 — Physical exam & vital signs 20:16 — Acetaminophen toxicity stages (1-4) 22:35 — Salicylate exam findings 23:43 — Lab workup & testing 24:45 — Acetaminophen nomogram & levels 30:39 — Activated charcoal — when to give it 34:11 — NAC therapy — dosing & timing 37:22 — Hemodialysis for acetaminophen 38:40 — King's College Criteria 41:00 — Salicylate treatment 44:42 — Potassium management during alkalinization 47:28 — Hemodialysis for salicylate 48:05 — Intubation 50:00 — Pregnancy considerations 51:20 — Pediatric considerations 52:06 — Emerging: fomepizole as adjunct therapy 52:45 — Summary & wrap-up Subscribers, take the CME test here. Emergency Medicine Residents, get your free subscription by writing [email protected]