Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the July 2026 Emergency Medicine Practice article, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management in the Emergency Department. 0:17 – Intro & sponsor promo 1:09 – Episode introduction 4:03 – Definitions: SJS vs. TEN vs. "overlap" by body surface area 6:12 – Pathophysiology 9:52 – Incidence and rarity of the disease 10:53 – Differential diagnosis & clinical presentation clues 12:08 – Prehospital care & fluid resuscitation considerations 13:47 – ED history-taking: medications, infections, rash progression 14:47 – Physical exam findings 16:46 – Diagnostic studies 18:12 – Scoring systems: SCORTEN and ABCD-10 20:50 – Treatment goals 23:57 – Wound care principles 24:43 – Mechanical ventilation risk factors 26:02 – Other possible therapies 27:50 – Specialty consults & special populations 29:06 – Ophthalmologic treatment 31:17 – HIV patients and elevated risk 31:55 – Emerging therapies & AI-based diagnostic tools 32:57 – Five key clinical takeaways 34:37 – Closing remarks & sponsor sign-off Subscribers, take the CME test here.  Emergency Medicine Residents, get your free subscription by writing [email protected]