60. The Gut and Immune System: The Histamine Connection

Could your gut help explain why you’re reacting to foods you once tolerated? In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact. A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the DAO enzyme—and why understanding the underlying contributors matters. What you’ll learn: How the intestinal barrier and secretory IgA help protect your gut. Why microbial diversity, butyrate and immune tolerance matter. How SIBO, dysbiosis and intestinal inflammation may contribute to histamine symptoms. How mast cells and certain gut bacteria produce histamine. Why intestinal health matters for DAO, the enzyme that helps break down dietary histamine. How stress, the nervous system, and gut motility can influence digestive symptoms. Why gut support needs to be personalised to your symptoms and tolerance. Whether you’re navigating histamine intolerance yourself or supporting patients in clinical practice, this episode offers a clearer understanding of the gut–immune connection. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!