This episode reviews a 2026 pilot study evaluating the effects of photobiomodulation therapy (PBMT) on inflammatory and cartilage biomarkers in patients with advanced knee osteoarthritis. We discuss the biologic rationale for PBMT, changes in serum and synovial fluid cytokines, and whether these findings move PBMT closer to being considered a disease-modifying intervention rather than simply a symptomatic treatment. <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12972950/#sec1-2">https://pmc.ncbi.nlm.nih.gov/articles/PMC12972950/#sec1-2 </a> Ferreira, Nathalia Lopes et al. “Photobiomodulation Therapy Modulates Inflammatory and Cartilage Biomarkers in Patients with Knee Osteoarthritis: A Pilot Case Series.” Journal of orthopaedic case reports vol. 16,3 (2026): 315-321. doi:10.13107/jocr.2026.v16.i03.6980 YouTube Channel View the many other episodes and videos available here <a href="https://www.youtube.com/channel/UCoSgtssCtVb0FX5tVZPSUng">Laser Therapy Institute</a> Further Resources:<a href="http://7415811.hs-sites.com/free-guide-for-laser-success">Success with Laser Therapy</a> Flowchart &amp; Checklist Infographic Check out these FREE <a href="https://www.lasertherapyinstitute.org/resources">Provider Resources </a>Read about laser research on the <a href="https://www.lasertherapyinstitute.org/blog">LTI Blog </a>Learn more about what we offer on the <a href="https://www.lasertherapyinstitute.org/">LTI website </a>Find out how you can <a href="https://meetings.hubspot.com/robertjbaker10">Customize your LTI experience</a>

<description>
 &lt;p&gt;&lt;br&gt;This episode reviews a 2026 pilot study evaluating the effects of photobiomodulation therapy (PBMT) on inflammatory and cartilage biomarkers in patients with advanced knee osteoarthritis. We discuss the biologic rationale for PBMT, changes in serum and synovial fluid cytokines, and whether these findings move PBMT closer to being considered a disease-modifying intervention rather than simply a symptomatic treatment. &lt;/p&gt;&lt;p&gt;&lt;a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12972950/#sec1-2"&gt;https://pmc.ncbi.nlm.nih.gov/articles/PMC12972950/#sec1-2&lt;br&gt;&lt;/a&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;Ferreira, Nathalia Lopes et al. “Photobiomodulation Therapy Modulates Inflammatory and Cartilage Biomarkers in Patients with Knee Osteoarthritis: A Pilot Case Series.” Journal of orthopaedic case reports vol. 16,3 (2026): 315-321. doi:10.13107/jocr.2026.v16.i03.6980&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;strong&gt;YouTube Channel&lt;br&gt;&lt;/strong&gt;View the many other episodes and videos available here &lt;a href="https://www.youtube.com/channel/UCoSgtssCtVb0FX5tVZPSUng"&gt;Laser Therapy Institute&lt;/a&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Further Resources:&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="http://7415811.hs-sites.com/free-guide-for-laser-success"&gt;Success with Laser Therapy&lt;/a&gt; Flowchart &amp;amp; Checklist Infographic&lt;br&gt;Check out these FREE &lt;a href="https://www.lasertherapyinstitute.org/resources"&gt;Provider Resources&lt;br&gt;&lt;/a&gt;Read about laser research on the &lt;a href="https://www.lasertherapyinstitute.org/blog"&gt;LTI Blog&lt;br&gt;&lt;/a&gt;Learn more about what we offer on the &lt;a href="https://www.lasertherapyinstitute.org/"&gt;LTI website&lt;br&gt;&lt;/a&gt;Find out how you can &lt;a href="https://meetings.hubspot.com/robertjbaker10"&gt;Customize your LTI experience&lt;/a&gt;&lt;/p&gt;
 </description>

STUDY: Laser and Osteoarthritis

Description