Coming off quetiapine for sleep: how slow is slow enough?

Quetiapine (Seroquel) is approved for schizophrenia and bipolar disorder, not for insomnia — yet low doses at bedtime are one of the most common off-label prescriptions people are handed for sleep. This episode walks through what the written guide says about coming off it: why the pace matters, what rebound insomnia is, and what the evidence for sleep actually looks like. We cover the common step-down of 25 to 50 percent every one to two weeks, why the last steps are usually the hardest, and the practical problem of reaching small doses — splitting immediate-release tablets with a pill cutter, using a liquid form, and never crushing extended-release tablets. We also look at the metabolic side of low-dose use, the symptoms that have been linked to stopping rapidly, and why cognitive behavioural therapy for insomnia (CBT-I) is the thing the guide suggests building while the dose comes down. Read the full guide: How to Safely Come Off Quetiapine (Seroquel) for Sleep. Looking for help with a taper? Find a provider trained in deprescribing. The hosts of this episode are AI-generated from the written guide on MyDeprescriber.com. Educational only, not medical advice. Never stop a medication without your provider. If you are in crisis in the US, call or text 988.