BIOCHEMISTRY - Krebs Cycle Rate-Limiting Step Vol 4 | NEET PG 2018 PYQ

🎧 High-Yield Daily Clinical Revision Podcast for NEET PG, FMGE, and INI-CET! 📖 Clinical Case Study: [Challenge Vol 4] A biochemistry researcher measures the rate of the Citric Acid Cycle under varying ATP levels. Which enzyme serves as the primary rate-limiting step of this pathway and is allosterically inhibited by high ATP? 📝 Options: • Option A: A. Isocitrate dehydrogenase • Option B: B. Citrate synthase • Option C: C. Alpha-ketoglutarate dehydrogenase • Option D: D. Malate dehydrogenase ✅ Correct Answer: Option A 💡 Explanation: Isocitrate dehydrogenase is the rate-limiting enzyme of the citric acid cycle (Krebs cycle). It converts isocitrate to alpha-ketoglutarate, producing NADH and CO2, and is inhibited by ATP and NADH, but stimulated by ADP. (Volume 4 High-Yield Concept Review) 🧠 Mnemonic: Krebs Cycle Rate Limiter V4 • Rate-limiting enzyme ➔ Isocitrate Dehydrogenase • Inhibitors ➔ ATP & NADH (signals high energy) • Activators ➔ ADP & Ca2+ (signals energy demand) ⚠️ Exam Trap to Avoid: Citrate synthase catalyzes the first reaction, but isocitrate dehydrogenase is the primary rate-limiting and regulated step. 🔗 Follow Us & Prepare Smart: • 📸 Instagram: instagram.com/drstemcell_1 • 🧵 Threads: threads.net/@drstemcell_1 • 📺 YouTube: youtube.com/@drstemcell-o2h • 👥 Facebook: facebook.com/drstemcell • 🍎 Apple Podcasts: Apple Podcasts Link 🏆 Join the discussion! Did you get this correct? Drop your option or score in the comments below! 👇 #NEETPG #FMGE #INICET #MBBS #DrStemCell #MedEd