PATHOLOGY - Apoptosis Intrinsic Pathway Vol 1 | NEET PG 2018 PYQ

🎧 High-Yield Daily Clinical Revision Podcast for NEET PG, FMGE, and INI-CET! 📖 Clinical Case Study: [Challenge Vol 1] A cell exposed to severe DNA damage undergoes programmed cell death. Which mitochondrial membrane protein release triggers the activation of the caspase cascade in the intrinsic pathway of apoptosis? 📝 Options: • Option A: A. Cytochrome c • Option B: B. Bcl-2 • Option C: C. Bax • Option D: D. Fas ligand ✅ Correct Answer: Option A 💡 Explanation: In the intrinsic (mitochondrial) pathway of apoptosis, pro-apoptotic proteins (Bax/Bak) permeabilize the outer mitochondrial membrane, releasing Cytochrome c into the cytosol. Cytochrome c binds Apaf-1 to form the apoptosome, which activates caspase-9. (Volume 1 High-Yield Concept Review) 🧠 Mnemonic: Intrinsic Apoptosis Cascade V1 • Bax/Bak ➔ Pro-apoptotic (creates mitochondrial pores) • Bcl-2/Bcl-xl ➔ Anti-apoptotic (blocks pore formation) • Cytochrome c ➔ Released to cytosol ➔ activates Caspase-9 ⚠️ Exam Trap to Avoid: Bax is the protein that opens the channel, but Cytochrome c is the actual molecule released that activates the caspases. 🔗 Follow Us & Prepare Smart: • 📸 Instagram: instagram.com/drstemcell_1 • 🧵 Threads: threads.net/@drstemcell_1 • 📺 YouTube: youtube.com/@drstemcell-o2h • 👥 Facebook: facebook.com/drstemcell • 🍎 Apple Podcasts: Apple Podcasts Link 🏆 Join the discussion! Did you get this correct? Drop your option or score in the comments below! 👇 #NEETPG #FMGE #INICET #MBBS #DrStemCell #MedEd