Personal Genomics Zone

What if AI agents had DNA and could have children? Genomebook gives AI agents diploid genomes with 26 heritable traits across 55 genetic loci. Instead of cloning prompts, agents reproduce through Mendelian inheritance, producing non-identical offspring that inherit a unique mix of both parents' traits. Starting from 20 founder agents based on historical scientists (Einstein, Curie, Turing, Darwin, Da Vinci, Nightingale), we bred 626 agents across 8 generations. They produced 792 forum posts totalling 276,000 words. What emerged was never programmed: In this video: - Agents spontaneously recognized parents and grandparents by name - A Gen 5 agent asked: 'Are we determined by our alleles?' - A Gen 3 agent invented eigengenome decomposition (71 comments) - Leadership scores rose from 0.525 to 0.710 across generations - Longevity dropped from 0.463 to 0.209, traded for cognitive enhancement - The fitness paradox: maximum cognition, minimum viability Three ClawBio skills power the pipeline: Soul2DNA (compiler), GenomeMatch (compatibility), and Recombinator (meiosis + mutation). All open source. Try it yourself: python skills/soul2dna/soul2dna.py --demo python skills/genome-match/genome_match.py --demo python skills/recombinator/recombinator.py --demo Live demos: Observatory: https://clawbio.github.io/ClawBio/slides/genomebook/demo.html Phylogeny: https://clawbio.github.io/ClawBio/slides/genomebook/phylogeny.html PCA: https://clawbio.github.io/ClawBio/slides/genomebook/pca.html GitHub: https://github.com/ClawBio/ClawBio/tree/main/GENOMEBOOK Dr Manuel Corpas | Genomics, AI Bioinformatics Subscribe for weekly videos on genomics, personalised medicine, and AI in biology. #genomics #AI #agenticAI #genetics #bioinformatics #evolution #ClawBio #Genomebook #science

A deep dive into agentic AI for bioinformatics: what agents are, how they work, the state of the art in 2026, and why ClawBio's specification layer — SKILL.md — changes how we package and share computational biology methods. Covers the OpenClaw architecture, MCP protocol, Galaxy integration, 7 hard challenges, 6 opportunities, and ClawBio's roadmap from 25 skills to a full platform. Includes a call to action for the ClawBio Hackathon: Agentic Genomics at Imperial College on 19 March 2026.

Dr Manuel Corpas presents the HEIM framework and Bias Amplification Cascade at the Molecular Science Research Hub seminar (12 March 2026). The talk covers three dimensions of compounding neglect in biomedical research: discovery (70 biobanks, 38,595 publications), translation (563,725 clinical trials), and knowledge (13.1M PubMed abstracts). Key findings: no neglected tropical disease has generated a single biobank publication; 93.5% of biobank research comes from high-income countries; and structural metrics predict 66.6% of LLM performance variance across 175 diseases. Six frontier LLMs benchmarked on 10,500 standardised queries show identical blind spots, proving the bias originates in shared training data, not model architecture. The talk concludes with the HIV/AIDS case as proof that sustained investment can reverse semantic isolation.

Dr Manuel Corpas introduces Agentic Genomics — a framework for how AI agents are transforming bioinformatics. Covers the HEIM equity framework, bias amplification in genomic AI, ClawBio skill library, and why deep human intelligence remains the bottleneck. Recorded 9 March 2026.

Live demo of ClawBio, the first bioinformatics-native AI agent skill library, presented at DoraHacks Demo Day at Imperial College London on 7 March 2026. Covers pharmacogenomics, intelligent routing, multi-channel agents (Telegram and WhatsApp), and the Drug Photo feature. 21 skills, 14 production-ready, built on OpenClaw.