<a href= "https://peterattiamd.com/endocrinesystem/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230529-pod-endocrinesystem&utm_content=230529-pod-endocrinesystem-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230529-pod-endocrinesystem&utm_content=230529-pod-endocrinesystem-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230529-pod-endocrinesystem&utm_content=230529-pod-endocrinesystem-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options for the treatment of hormone deficiencies. In addition, Peter delves into hormone replacement therapy (HRT), providing nuanced insights into its appropriate usage and the clinical approach he adopts when working with patients.   Peter supplements these explanations with whiteboard illustrations. For a more complete understanding, we highly recommend watching these videos over just listening. The videos can be found on our YouTube channel or on the show notes page. We discuss: <ul type="disc"> <li>The thyroid system [2:15];</li> <li>The adrenal system [15:45];</li> <li>The female sex hormone system [27:00];</li> <li>The male sex hormone system [40:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

<a href= "https://peterattiamd.com/endocrinesystem/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230529-pod-endocrinesystem&utm_content=230529-pod-endocrinesystem-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230529-pod-endocrinesystem&utm_content=230529-pod-endocrinesystem-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230529-pod-endocrinesystem&utm_content=230529-pod-endocrinesystem-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options for the treatment of hormone deficiencies. In addition, Peter delves into hormone replacement therapy (HRT), providing nuanced insights into its appropriate usage and the clinical approach he adopts when working with patients.   Peter supplements these explanations with whiteboard illustrations. For a more complete understanding, we highly recommend watching these videos over just listening. The videos can be found on our YouTube channel or on the show notes page. We discuss: <ul type="disc"> <li>The thyroid system [2:15];</li> <li>The adrenal system [15:45];</li> <li>The female sex hormone system [27:00];</li> <li>The male sex hormone system [40:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the...

#256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D.

<a href= "https://peterattiamd.com/johnkastelein/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230522-pod-johnkastelein&utm_content=230522-pod-johnkastelein-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230522-pod-johnkastelein&utm_content=230522-pod-johnkastelein-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230522-pod-johnkastelein&utm_content=230522-pod-johnkastelein-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> John Kastelein is a renowned expert in lipoprotein metabolism and atherosclerotic cardiovascular disease (ASCVD) research. In this discussion, John delves deep into familial hypercholesterolemia (FH), a genetic disorder characterized by high levels of LDL cholesterol in the blood that increases the risk of developing heart disease. He covers its definition, genetic underpinnings, and clinical identification. He then explores the therapeutic options available for the prevention and treatment of cardiovascular disease, including the captivating history of CETP inhibitors. He explains the past shortcomings of previous CETP inhibitors before underscoring the compelling potential of the latest iterations, not only for cardiovascular disease but also for conditions like Alzheimer's disease and type 2 diabetes. Moreover, he unveils the intricate role of APOE, shedding light on why the APOE4 isoform codes for a protein that significantly increases the risk of Alzheimer's disease and cardiovascular disease. Concluding the discussion, John shares a profound sense of optimism, envisioning the possibility of targeted therapeutic interventions for high-risk patients in the near future. We discuss: <ul type="disc"> <li>Familial hypercholesterolemia (FH): a genetic condition [4:30];</li> <li>Differentiating between phenotype and genotype when it comes to FH [9:45];</li> <li>The pathophysiology related to mutations of FH [15:30];</li> <li>Clinical presentations, physical manifestations, and diagnosis of FH [22:00];</li> <li>Why a small fraction of people with FH do not develop premature ASCVD [34:15];</li> <li>Treatment and prevention for those with FH [39:45];</li> <li>Addressing the assertion by some that elevated LDL is not casual in cardiovascular disease [52:45];</li> <li>The history of CETP inhibitors, and the role of the CETP protein [55:45];</li> <li>The thrifty gene hypothesis and why genes underlying FH may have been preserved [1:09:00];</li> <li>The compelling potential of the latest CETP inhibitor (obicetrapib) [1:13:00];</li> <li>Promising results from phase 3 trials exploring obicetrapib [1:27:45];</li> <li>Why the APOE4 allele increases the risk of Alzheimer’s disease, and the connection to blood lipids [1:41:30];</li> <li>The role of APOE in cardiovascular disease [1:51:45];</li> <li>Takeaways and looking ahead [1:57:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

<a href= "https://peterattiamd.com/johnkastelein/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230522-pod-johnkastelein&utm_content=230522-pod-johnkastelein-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230522-pod-johnkastelein&utm_content=230522-pod-johnkastelein-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230522-pod-johnkastelein&utm_content=230522-pod-johnkastelein-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> John Kastelein is a renowned expert in lipoprotein metabolism and atherosclerotic cardiovascular disease (ASCVD) research. In this discussion, John delves deep into familial hypercholesterolemia (FH), a genetic disorder characterized by high levels of LDL cholesterol in the blood that increases the risk of developing heart disease. He covers its definition, genetic underpinnings, and clinical identification. He then explores the therapeutic options available for the prevention and treatment of cardiovascular disease, including the captivating history of CETP inhibitors. He explains the past shortcomings of previous CETP inhibitors before underscoring the compelling potential of the latest iterations, not only for cardiovascular disease but also for conditions like Alzheimer's disease and type 2 diabetes. Moreover, he unveils the intricate role of APOE, shedding light on why the APOE4 isoform codes for a protein that significantly increases the risk of Alzheimer's disease and cardiovascular disease. Concluding the discussion, John shares a profound sense of optimism, envisioning the possibility of targeted therapeutic interventions for high-risk patients in the near future. We discuss: <ul type="disc"> <li>Familial hypercholesterolemia (FH): a genetic condition [4:30];</li> <li>Differentiating between phenotype and genotype when it comes to FH [9:45];</li> <li>The pathophysiology related to mutations of FH [15:30];</li> <li>Clinical presentations, physical manifestations, and diagnosis of FH [22:00];</li> <li>Why a small fraction of people with FH do not develop premature ASCVD [34:15];</li> <li>Treatment and prevention for those with FH [39:45];</li> <li>Addressing the assertion by some that elevated LDL is not casual in cardiovascular disease [52:45];</li> <li>The history of CETP inhibitors, and the role of the CETP protein [55:45];</li> <li>The thrifty gene hypothesis and why genes underlying FH may have been preserved [1:09:00];</li> <li>The compelling potential of the latest CETP inhibitor (obicetrapib) [1:13:00];</li> <li>Promising results from phase 3 trials exploring obicetrapib [1:27:45];</li> <li>Why the APOE4 allele increases the risk of Alzheimer’s disease, and the connection to blood lipids [1:41:30];</li> <li>The role of APOE in cardiovascular disease [1:51:45];</li> <li>Takeaways and looking ahead [1:57:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

John Kastelein is a renowned expert in lipoprotein metabolism and atherosclerotic cardiovascular disease (ASCVD) research. In this discussion, John delves deep into familial hypercholesterolemia (FH), a genetic disorder characterized by high levels of...

#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

<a href= "https://peterattiamd.com/ama47/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> In this “Ask Me Anything” (AMA) episode, Peter delves deep into the data surrounding different forms of cold therapy, including cold water immersion, cryotherapy, and cold showers, aiming to unveil the potential benefits and drawbacks associated with cold therapy. He dissects the studies examining the effects of cold therapy on delayed onset muscle soreness (DOMS), activation of brown adipose tissue, and its potential impact on mood and as a therapeutic approach for depression. Furthermore, Peter discusses the potential negative impact cold therapy may have on muscular hypertrophy and offers his perspective on the extent to which the data support the notion of cold therapy providing longevity benefits. Finally, he also discusses the existing consensus, or lack thereof, regarding the optimal structure of an effective cold therapy protocol. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your <a href= "https://peterattiamd.com/members/private-podcast-feed/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed">private RSS feed </a>or our website at the <a href= "http://peterattiamd.com/ama47/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed">AMA #47 show notes page</a>. If you are not a subscriber, you can learn more about the subscriber benefits <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed">here</a>. We discuss: <ul type="disc"> <li>Overview of discussion on cold therapy (and a Formula 1 tangent) [1:45];</li> <li>The most common cold exposure therapies [5:45];</li> <li>Potential benefits of cold water immersion: a look at the data [9:30];</li> <li>Comparing the effects of cold water immersion with whole-body cryotherapy [18:30];</li> <li>The potential impact of cold exposure on mood and as a treatment for depression [20:45];</li> <li>How do cold showers compare to cold water immersion? [28:15];</li> <li>Cold exposure and the activation of brown adipose tissue (BAT) [34:15];</li> <li>Things that clearly impact brain health: smoking, alcohol, sleep, head injuries, blood pressure, and more [34:15];</li> <li>Exercising in cold temperatures: impact on exercise performance [38:30];</li> <li>Potential downsides of cold therapy and its impact on hypertrophy, strength, and recovery [44:45];</li> <li>Are the blunting effects of cold on hypertrophy due to the effects on inflammation? [50:45];</li> <li>Does cold exposure offer any potential geroprotective benefits? [53:15];</li> <li>Cold therapy protocols for delayed onset muscle soreness (DOMS) [56:30];</li> <li>Summarizing the data and takeaways from Peter [1:01:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

<a href= "https://peterattiamd.com/ama47/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> In this “Ask Me Anything” (AMA) episode, Peter delves deep into the data surrounding different forms of cold therapy, including cold water immersion, cryotherapy, and cold showers, aiming to unveil the potential benefits and drawbacks associated with cold therapy. He dissects the studies examining the effects of cold therapy on delayed onset muscle soreness (DOMS), activation of brown adipose tissue, and its potential impact on mood and as a therapeutic approach for depression. Furthermore, Peter discusses the potential negative impact cold therapy may have on muscular hypertrophy and offers his perspective on the extent to which the data support the notion of cold therapy providing longevity benefits. Finally, he also discusses the existing consensus, or lack thereof, regarding the optimal structure of an effective cold therapy protocol. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your <a href= "https://peterattiamd.com/members/private-podcast-feed/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed">private RSS feed </a>or our website at the <a href= "http://peterattiamd.com/ama47/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed">AMA #47 show notes page</a>. If you are not a subscriber, you can learn more about the subscriber benefits <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230515-pod-ama47&utm_content=230515-pod-ama47-podfeed">here</a>. We discuss: <ul type="disc"> <li>Overview of discussion on cold therapy (and a Formula 1 tangent) [1:45];</li> <li>The most common cold exposure therapies [5:45];</li> <li>Potential benefits of cold water immersion: a look at the data [9:30];</li> <li>Comparing the effects of cold water immersion with whole-body cryotherapy [18:30];</li> <li>The potential impact of cold exposure on mood and as a treatment for depression [20:45];</li> <li>How do cold showers compare to cold water immersion? [28:15];</li> <li>Cold exposure and the activation of brown adipose tissue (BAT) [34:15];</li> <li>Things that clearly impact brain health: smoking, alcohol, sleep, head injuries, blood pressure, and more [34:15];</li> <li>Exercising in cold temperatures: impact on exercise performance [38:30];</li> <li>Potential downsides of cold therapy and its impact on hypertrophy, strength, and recovery [44:45];</li> <li>Are the blunting effects of cold on hypertrophy due to the effects on inflammation? [50:45];</li> <li>Does cold exposure offer any potential geroprotective benefits? [53:15];</li> <li>Cold therapy protocols for delayed onset muscle soreness (DOMS) [56:30];</li> <li>Summarizing the data and takeaways from Peter [1:01:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

In this “Ask Me Anything” (AMA) episode, Peter delves deep into the data surrounding different forms of cold therapy, including cold water immersion, cryotherapy, and cold showers, aiming to unveil the potential benefits and drawbacks associated...

#254 - AMA #47: Cold therapy: pros, cons, and its impact on longevity

<a href= "https://peterattiamd.com/joannmanson/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230412-pod-joannmanson&utm_content=230412-pod-joannmanson-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230412-pod-joannmanson&utm_content=230412-pod-joannmanson-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230412-pod-joannmanson&utm_content=230412-pod-joannmanson-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> JoAnn Manson is a world-renowned endocrinologist, epidemiologist, and Principal Investigator for the Women’s Health Initiative (WHI). In this episode, she dives deep into the WHI to explain the study design, primary outcome, confounding factors, and nuanced benefits and risks of hormone replacement therapy (HRT). JoAnn reflects on how a misinterpretation of the results, combined with sensationalized headlines regarding an elevated risk of breast cancer, led to a significant shift in the perception and utilization of HRT. From there, they take a closer look at the breast cancer data to separate fact from fiction. Additionally, JoAnn gives her take on how one should weigh the risks and benefits of HRT and concludes with a discussion on how physicians can move towards better HRT practices. We discuss: <ul type="disc"> <li>The Women’s Health Initiative: the original goal of the study, hormone formulations used, and potential confounders [4:15];</li> <li>Study design of the Women’s Health Initiative, primary outcome, and more [16:00];</li> <li>JoAnn’s personal hypothesis about the ability of hormone replacement therapy to reduce heart disease risk prior to the WHI [26:45];</li> <li>The relationship between estrogen and breast cancer [30:45];</li> <li>Why the WHI study was stopped early, and the dramatic change in the perception and use of HRT due to the alleged increase in breast cancer risk [37:30];</li> <li>What Peter finds most troubling about the mainstream view of HRT and a more nuanced look at the benefits and risks of HRT [45:15];</li> <li>HRT and bone health [56:00];</li> <li>The importance of timing when it comes to HRT, the best use cases, and advice on finding a clinician [59:30];</li> <li>A discussion on the potential impact of HRT on mortality and a thought experiment on a long-duration use of HRT [1:03:15];</li> <li>Moving toward better HRT practices, and the need for more studies [1:10:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

<a href= "https://peterattiamd.com/joannmanson/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230412-pod-joannmanson&utm_content=230412-pod-joannmanson-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230412-pod-joannmanson&utm_content=230412-pod-joannmanson-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230412-pod-joannmanson&utm_content=230412-pod-joannmanson-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> JoAnn Manson is a world-renowned endocrinologist, epidemiologist, and Principal Investigator for the Women’s Health Initiative (WHI). In this episode, she dives deep into the WHI to explain the study design, primary outcome, confounding factors, and nuanced benefits and risks of hormone replacement therapy (HRT). JoAnn reflects on how a misinterpretation of the results, combined with sensationalized headlines regarding an elevated risk of breast cancer, led to a significant shift in the perception and utilization of HRT. From there, they take a closer look at the breast cancer data to separate fact from fiction. Additionally, JoAnn gives her take on how one should weigh the risks and benefits of HRT and concludes with a discussion on how physicians can move towards better HRT practices. We discuss: <ul type="disc"> <li>The Women’s Health Initiative: the original goal of the study, hormone formulations used, and potential confounders [4:15];</li> <li>Study design of the Women’s Health Initiative, primary outcome, and more [16:00];</li> <li>JoAnn’s personal hypothesis about the ability of hormone replacement therapy to reduce heart disease risk prior to the WHI [26:45];</li> <li>The relationship between estrogen and breast cancer [30:45];</li> <li>Why the WHI study was stopped early, and the dramatic change in the perception and use of HRT due to the alleged increase in breast cancer risk [37:30];</li> <li>What Peter finds most troubling about the mainstream view of HRT and a more nuanced look at the benefits and risks of HRT [45:15];</li> <li>HRT and bone health [56:00];</li> <li>The importance of timing when it comes to HRT, the best use cases, and advice on finding a clinician [59:30];</li> <li>A discussion on the potential impact of HRT on mortality and a thought experiment on a long-duration use of HRT [1:03:15];</li> <li>Moving toward better HRT practices, and the need for more studies [1:10:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

JoAnn Manson is a world-renowned endocrinologist, epidemiologist, and Principal Investigator for the Women’s Health Initiative (WHI). In this episode, she dives deep into the WHI to explain the study design, primary outcome, confounding factors, and...

#253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D.

<a href= "https://peterattiamd.com/rhondapatrick2/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230501-pod-rhondapatrick2&utm_content=230501-pod-rhondapatrick2-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230501-pod-rhondapatrick2&utm_content=230501-pod-rhondapatrick2-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230501-pod-rhondapatrick2&utm_content=230501-pod-rhondapatrick2-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> Rhonda Patrick, Ph.D., is a scientist with expertise in the areas of aging, cancer, and nutrition who translates complex scientific topics into actionable insights on her podcast, Found My Fitness. In this episode, Rhonda provides her latest thinking as it relates to Alzheimer's disease including the possibility of a vascular hypothesis as well as the factors that can impact disease risk such as type 2 diabetes, blood pressure, omega supplementation, exercise, sauna, and more. She also touches on cancer risk including the relationship between cancer and exercise as well as the link between alcohol consumption and cancer. Additionally, Rhonda explains her new focus on exercise and protein consumption as well as how her perspective has shifted as it pertains to fasting and time-restricted feeding. We discuss: <ul type="disc"> <li>Alzheimer’s disease: Rhonda’s evolved thinking on neurodegenerative diseases [2:30];</li> <li>The breakdown of the blood-brain barrier in neurodegenerative disease [8:45];</li> <li>An explanation for the observation that type 2 diabetes increases risk of Alzheimer’s disease [15:45];</li> <li>The role of omega-3 fatty acids (EPA and DHA) in brain health and prevention of neurodegeneration [19:45];</li> <li>Comparing the preventable nature of type 2 diabetes, atherosclerosis, cancer, and dementia [32:15];</li> <li>Blood pressure: an important modifiable lifestyle factor that can affect Alzheimer's disease risk [35:15];</li> <li>Rhonda’s outlook on “precision medicine” as it pertains to one’s genetic predispositions [38:45];</li> <li>Possible mechanisms by which exercise reduces the risk of Alzheimer’s disease [45:45];</li> <li>Building your aerobic pyramid: neurobiological effects of exercise, benefits of lactate peaks, and more [53:45];</li> <li>Maximizing mitochondrial biogenesis: alternative training approaches and strategies [58:45];</li> <li>Possible brain benefits of sauna, and Rhonda’s personal protocol [1:09:30];</li> <li>The relationship between cardiorespiratory fitness and dementia risk [1:15:30];</li> <li>How exercise may reduce the risk of cancer [1:20:30];</li> <li>The overarching impact of exercise on health, and the importance of focusing the factors that matter most [1:33:15];</li> <li>Impact of alcohol consumption on breast cancer risk and overall health [1:37:15];</li> <li>Exercise as an intervention for poor sleep habits [1:42:30];</li> <li>The longevity benefits of consuming adequate protein and strength training to preserve muscle mass and strength [1:46:30];</li> <li>How to get enough of the right kind of protein in your diet [2:05:15];</li> <li>Fasting: weighing the risk vs. reward [2:12:15];</li> <li>How Rhonda’s views have shifted on diet and exercise [2:15:30];</li> <li>How to follow Rhonda’s work and more about the benefits of lactate for the brain [2:21:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

<a href= "https://peterattiamd.com/rhondapatrick2/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230501-pod-rhondapatrick2&utm_content=230501-pod-rhondapatrick2-podfeed"> View the Show Notes Page for This Episode</a> <a href= "https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230501-pod-rhondapatrick2&utm_content=230501-pod-rhondapatrick2-podfeed"> Become a Member to Receive Exclusive Content</a> <a href= "https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=230501-pod-rhondapatrick2&utm_content=230501-pod-rhondapatrick2-podfeed"> Sign Up to Receive Peter’s Weekly Newsletter</a> Rhonda Patrick, Ph.D., is a scientist with expertise in the areas of aging, cancer, and nutrition who translates complex scientific topics into actionable insights on her podcast, Found My Fitness. In this episode, Rhonda provides her latest thinking as it relates to Alzheimer's disease including the possibility of a vascular hypothesis as well as the factors that can impact disease risk such as type 2 diabetes, blood pressure, omega supplementation, exercise, sauna, and more. She also touches on cancer risk including the relationship between cancer and exercise as well as the link between alcohol consumption and cancer. Additionally, Rhonda explains her new focus on exercise and protein consumption as well as how her perspective has shifted as it pertains to fasting and time-restricted feeding. We discuss: <ul type="disc"> <li>Alzheimer’s disease: Rhonda’s evolved thinking on neurodegenerative diseases [2:30];</li> <li>The breakdown of the blood-brain barrier in neurodegenerative disease [8:45];</li> <li>An explanation for the observation that type 2 diabetes increases risk of Alzheimer’s disease [15:45];</li> <li>The role of omega-3 fatty acids (EPA and DHA) in brain health and prevention of neurodegeneration [19:45];</li> <li>Comparing the preventable nature of type 2 diabetes, atherosclerosis, cancer, and dementia [32:15];</li> <li>Blood pressure: an important modifiable lifestyle factor that can affect Alzheimer's disease risk [35:15];</li> <li>Rhonda’s outlook on “precision medicine” as it pertains to one’s genetic predispositions [38:45];</li> <li>Possible mechanisms by which exercise reduces the risk of Alzheimer’s disease [45:45];</li> <li>Building your aerobic pyramid: neurobiological effects of exercise, benefits of lactate peaks, and more [53:45];</li> <li>Maximizing mitochondrial biogenesis: alternative training approaches and strategies [58:45];</li> <li>Possible brain benefits of sauna, and Rhonda’s personal protocol [1:09:30];</li> <li>The relationship between cardiorespiratory fitness and dementia risk [1:15:30];</li> <li>How exercise may reduce the risk of cancer [1:20:30];</li> <li>The overarching impact of exercise on health, and the importance of focusing the factors that matter most [1:33:15];</li> <li>Impact of alcohol consumption on breast cancer risk and overall health [1:37:15];</li> <li>Exercise as an intervention for poor sleep habits [1:42:30];</li> <li>The longevity benefits of consuming adequate protein and strength training to preserve muscle mass and strength [1:46:30];</li> <li>How to get enough of the right kind of protein in your diet [2:05:15];</li> <li>Fasting: weighing the risk vs. reward [2:12:15];</li> <li>How Rhonda’s views have shifted on diet and exercise [2:15:30];</li> <li>How to follow Rhonda’s work and more about the benefits of lactate for the brain [2:21:00]; and</li> <li>More.</li> </ul> Connect With Peter on <a href= "https://twitter.com/PeterAttiaMD">Twitter</a>, <a href= "https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a>

Rhonda Patrick, Ph.D., is a scientist with expertise in the areas of aging, cancer, and nutrition who translates complex scientific topics into actionable insights on her podcast, Found My Fitness. In this episode, Rhonda provides her latest thinking...

#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.

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