Oct 23, 2026 This Week in Cardiology Podcast

Listener feedback on the nonobstructive HCM trials, AI-enhanced visits, timing of non-culprit PCI in STEMI, new tricuspid valve intervention, and EP at a crossroads are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Koelemen meta-analysis https://www.medrxiv.org/content/10.64898/2026.09.08.26362195v1.full.pdf Improving SCD Risk Stratification in HCM https://pmc.ncbi.nlm.nih.gov/articles/PMC11026183/ II More on Nonobstructive HCM Communication on Post-Hoc Analysis of ODYSSEY (mavacamten) Mavacamten in Nonobstructive HCM 10.1016/j.jacc.2025.12.092 III Complete vs Staged PCI in STEMI With Multivessel Disease Immediate vs Staged CR in Multivessel Disease and STEMI: Meta-Analysis https://doi.org/10.1016/j.jcin.2026.07.033 Timing of Nonculprit PCI for STEMI and Multivessel Disease: Editorial https://doi.org/10.1016/j.jcin.2026.08.009 COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775 FLOWER MI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2104650 FRAME AMI Trial https://doi.org/10.1093/eurheartj/ehac763 iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918 COCUA Trial https://doi.org/10.1016/j.ahj.2023.01.020 MULTISTARS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823 OPTION STEMI Trial 10.1016/S0140-6736(25)01529-6 External Link CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261 BioVasc Trial Substudy https://eurointervention.pcronline.com/article/immediate-versus-staged-complete-revascularisation-in-patients-presenting-with-stemi-and-multivessel-disease Main BioVasc Trial 10.1016/S0140-6736(23)00351-3 External Link FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149 IV A Call to Action for Electrophysiologists Twenty Years at the Crossroads 10.1016/j.jacep.2026.09.023 EP at a Crossroads - Josephson 2007 https://doi.org/10.1016/j.hrthm.2006.12.045 EP at a Crossroads: A Revisit - Josephson 2016 https://doi.org/10.1016/j.hrthm.2016.07.024 V FDA Approves Another Tricuspid Valve Repair System Press release https://www.edwards.com/newsroom/news/2026-10-21-fda-approval-of-edwards-lifesciences--pascal-preci TRIC I HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934 CLASP II TR Trial https://pubmed.ncbi.nlm.nih.gov/42855029/ The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact [email protected] Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.