NMN, NAD+ and other acronyms of anti-aging

As we age, levels of a vital molecule called nicotinamide adenine dinucleotide (NAD+) decline. Could reversing this be the key to eternal youth? There’s huge interest in NAD-boosting supplements like nicotinamide mononucleotide (NMN). But is there good evidence that they can help us live longer, healthier? Norman and Tegan unpack how NAD+ became the focus of anti-aging proponents. This episode first aired on November 4, 2024. References: NAD+ metabolism and its roles in cellular processes during ageing NAD+ in Brain Aging and Neurodegenerative Disorders What is really known about the effects of nicotinamide riboside supplementation in humans Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions The use of a systems approach to increase NAD+ in human participants Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging