#213 Hypertension First-Line Medications Troubleshooting | Bread & Butter Series

Why can lower-dose combinations be more effective and better tolerated than maximizing one medication? How to troubleshoot common challenges such as amlodipine edema, gout, electrolyte abnormalities, and the patient who says they cannot tolerate anything? Why ACT (ARBs, Calcium Channel Blockers, Thiazides) is the preferred first-line framework, and how to personalize medication choices based on comorbidities and side effects. 🔹Sponsor: Oakstone CME Use the code "CORE25" for 25% off: https://www.coreimpodcast.com/MKSAP  🔹Transcript and Shownotes 03:00 | Diagnosing Hypertension  04:10 | When to Start Combination Therapy Instead of Monotherapy  07:00 | Choosing First-Line Therapy Using the ACT Framework  13:23 | Why ARBs Are Often Preferred Over ACE Inhibitors  16:02 | Choosing the Right ARB: Candesartan vs Losartan  18:39 | Comparing Potency & Duration Across First-Line Antihypertensives  20:54 | Amlodipine Edema: Why It Happens and How to Fix It  23:54 | Thiazides: Practical Tips, Electrolyte Problems & Class-Killer Side Effects  29:33 | Managing Patients Who 'Can't Tolerate' Blood Pressure Medications  Tags: Hypertension Management, High Blood Pressure, Primary Care, Internal Medicine, Core IM Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy