ALS and ketamine therapy are at the center of this conversation with psychiatrist Dr. Michael Alpert and Peter Alberding, who was diagnosed with ALS in late 2023. Alpert is a Boston-area psychiatrist with experience in MDMA-assisted therapy research for PTSD and a private practice that includes ketamine-assisted psychotherapy. Alberding shares what it has been like to face a fatal neurodegenerative illness while working with ketamine in a structured clinical setting. Alberding explains that he was not looking for a casual psychedelic experience. He wanted help facing fear, grief, loss of function, and the reality of death. Over time, ketamine-assisted psychotherapy became a tool for processing those changes more directly than talk therapy alone had allowed.