<p>The San Francisco 49ers take on the Indianapolis Colts in apivotal Week 16 matchup with massive playoff implications. Riding a four-game winning streak, the 49ers need just one more win to clinch a playoff spot — but the Colts are desperate to keep their slim postseason hopes alive.</p><p>In this podcast, we break down how Brock Purdy and the 49ers offense match up against a Colts defense that’s been vulnerable through the air, and whether San Francisco’s struggling run defense can slow down NFL rushing leader Jonathan Taylor. </p><p>We also dive into Philip Rivers’ role as a point-guard quarterback, key injury storylines, trench battles, and why tackling will decide this game.</p><p>Will the 49ers continue their improbable playoff push, orwill the Colts play spoiler in Week 16?</p><p><strong>Topics Covered:</strong></p><ul><li>49ers vs. Colts Week 16 preview</li><li>NFL Playoff scenarios &amp; clinching paths</li><li>Brock Purdy matchup breakdown</li><li>Jonathan Taylor vs. 49ers run defense</li><li>George Kittle &amp; 49ers&#39; passing advantages</li><li>Keys to victory and final prediction</li></ul><p>👍 Like, subscribe, anddrop your score prediction in the comments.</p><p>Purchase G.O.A.T Fuel: <a href="https://goatfuel.com/?rfsn=8542698.99750d3">⁠⁠https://goatfuel.com/?rfsn=8542698.99750d3⁠⁠</a></p><p>Visit Sports Spyder for up to date 49ers content: <a href="https://sportspyder.com/nfl/san-francisco-49ers/news">⁠⁠https://sportspyder.com/nfl/san-francisco-49ers/news⁠⁠</a></p><p>Follow us on Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @49ers_Access⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠</p><p>Follow us on Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@49ers.access  </p>