Adam May on $ABVX's blowout data and subsequent stock crash
JUN 10, 202673 MIN
Adam May on $ABVX's blowout data and subsequent stock crash
JUN 10, 202673 MIN
Description
<p>Abivax posted maybe the best ulcerative colitis data anyone's seen, then crashed 60% on a cancer signal Adam May argues is statistical noise. We dig into whether $ABVX is now a mispriced takeout: the maintenance efficacy that beat Rinvoq, how the scary "seven cancer cases" collapse to two, the blackbox question, the Crohn's skew, and the part two safety data due within weeks. Then a quick look at Nectar (NKTR), its alopecia areata data, and the Eli Lilly lawsuit.</p><p>This episode is s<a href="https://www.alpha-sense.com/resources/webinars/choosing-your-ai-stack-a-framework-for-institutional-investors/?utm_source=pt_YAVP&utm_medium=sponsored&utm_campaign=SWB_DG_06-25-26_IMP-GENAI_CORPFS_YAVP-AI-Solutions" target="_blank" rel="noopener noreferer">ponsored by AlphaSense, and specifically Andrew's upcoming AI webinar with them:</a> breaking down the modern AI stack for investors with Dave Wang (Wall Street Prompts) and Ben Collins (AlphaSense). <a href="https://www.alpha-sense.com/resources/webinars/choosing-your-ai-stack-a-framework-for-institutional-investors/?utm_source=pt_YAVP&utm_medium=sponsored&utm_campaign=SWB_DG_06-25-26_IMP-GENAI_CORPFS_YAVP-AI-Solutions" target="_blank" rel="noopener noreferer">Goes live June 25. Register here. </a></p><p>Chapters:</p><p>00:00 Intro and disclosure (long ABVX and NKTR)</p><p>01:03 Sponsor: AlphaSense AI webinar for investors</p><p>02:33 The biotech "GOAT" returns</p><p>03:33 Abivax setup: induction vs maintenance, the stakes</p><p>06:38 The bar: clinical remission and Rinvoq</p><p>10:14 Blowout maintenance data, and endoscopic remission that doubles Rinvoq</p><p>14:23 The data drops, then a 60% crash</p><p>16:31 The cancer scare, taken apart case by case</p><p>24:45 Why it's statistical noise: mechanism, clustering, base rates</p><p>28:50 Adverse-event capture and the phase 2 safety database</p><p>33:57 Bear case: hasn't the market had time to digest this?</p><p>38:00 Blackbox or no blackbox, and does it matter at $100</p><p>40:32 The Crohn's readout and the skew</p><p>45:36 M&A: timing, the new CCO, what Adam wants them to do</p><p>47:38 Part two safety data due within weeks</p><p>54:46 The cash question: secondary vs sale</p><p>57:49 Nectar: strong data, then an unexplained selloff</p><p>59:54 The Eli Lilly lawsuit and the jury-trial angle</p><p>01:03:26 Ox40 read-through and the Q32 Bio overhang</p><p>01:06:07 Most mispriced pick, targets, and the CEO's Cincor parallel</p><p>01:12:10 Wrap</p><p>Links:</p><p>Yet Another Value Blog - https://www.yetanothervalueblog.com</p><p>See our legal disclaimer here: https://www.yetanothervalueblog.com/p/legal-and-disclaimer</p><p>Production and editing by The Podcast Consultant - https://thepodcastconsultant.com/</p><p>Disclosure: Long ABVX and NKTR</p>