<description>&lt;p dir="ltr"&gt;Are you protecting your immune system as you age?&lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;In this Longevity podcast episode, I am joined by Dr. Anurag Singh to discuss recent research that suggests Urolithin A, a compound derived from pomegranates and other foods, may help rejuvenate the aging immune system. &lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;We dive into how supplementing with Urolithin A for just 4 weeks led to significant improvements in immune cell function and a reduction in biological age by an average of 2 years in middle-aged adults. We also discuss insights on dosing, combining Urolithin A with other longevity strategies, and ongoing clinical trials that may reveal even more benefits.&lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;Dr. Anurag Singh is the Chief Medical Officer of Timeline Nutrition, a biotech company focused on discovering and developing next generation natural compounds that target improvement in mitochondrial health. He began his career in 2003 as a Resident Medical Doctor at Northern Railway Divisional Hospital in Lucknow. &lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;Go to &lt;a href= "http://timelinenutrition.com/nat10"&gt;TimelineNutrition.com/nat10&lt;/a&gt; and/or use code Nat10 for a discount.&lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;Thank you to our sponsors for making this episode possible:                                                                                                                                                          &lt;/p&gt; &lt;p dir="ltr"&gt;Element Health: Use code Longevity when shopping at &lt;a href= "https://elementhealthsupply.com/discount/Longevity"&gt;https://elementhealthsupply.com/discount/Longevity&lt;/a&gt;  to save on your orders.&lt;/p&gt; &lt;p dir="ltr"&gt;Siphox: Visit &lt;a href= "http://siphoxhealth.com/nat"&gt;http://SiPhoxhealth.com/nat&lt;/a&gt;  and save on your test. &lt;/p&gt; &lt;p dir="ltr"&gt;                                                                                                                                            &lt;/p&gt; &lt;p dir="ltr"&gt;Find more from Dr. Singh/Timeline: &lt;/p&gt; &lt;p dir="ltr"&gt;Website: &lt;a href= "http://timelinenutrition.com/nat10"&gt;www.timelinenutrition.com&lt;/a&gt; &lt;/p&gt; &lt;p dir="ltr"&gt;Instagram: &lt;a href= "https://www.instagram.com/timeline_longevity/"&gt;@timeline_longevity&lt;/a&gt;&lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;Find more from Nathalie:&lt;/p&gt; &lt;p dir="ltr"&gt;YouTube: &lt;a href= "https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ"&gt;https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ&lt;/a&gt; &lt;/p&gt; &lt;p dir="ltr"&gt;Join Nat’s Membership Community: &lt;a href= "https://www.natniddam.com/bsp-community"&gt;https://www.natniddam.com/bsp-community&lt;/a&gt; &lt;/p&gt; &lt;p dir="ltr"&gt;Sign up for Nats Newsletter: &lt;a href= "https://landing.mailerlite.com/webforms/landing/i7d5m0"&gt;https://landing.mailerlite.com/webforms/landing/i7d5m0&lt;/a&gt; &lt;/p&gt; &lt;p dir="ltr"&gt;Instagram: &lt;a href= "https://www.instagram.com/nathalieniddam/"&gt;https://www.instagram.com/nathalieniddam/&lt;/a&gt; &lt;/p&gt; &lt;p dir="ltr"&gt;Website: &lt;a href= "http://www.natniddam.com"&gt;www.NatNiddam.com&lt;/a&gt;   &lt;/p&gt; &lt;p dir="ltr"&gt;Facebook Group: &lt;a href= "https://www.facebook.com/groups/biohackingsuperhumanperformance"&gt;https://www.facebook.com/groups/biohackingsuperhumanperformance&lt;/a&gt; &lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;What We Discuss:&lt;/p&gt; &lt;p&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;09:04 The Role of the Immune System in Aging&lt;/p&gt; &lt;p dir="ltr"&gt;12:10 Understanding Immune Exhaustion and Inflammation&lt;/p&gt; &lt;p dir="ltr"&gt;15:12 Mitochondrial Health and Immune Function&lt;/p&gt; &lt;p dir="ltr"&gt;18:06 Urolithin A: Sources and Production&lt;/p&gt; &lt;p dir="ltr"&gt;12:05 Research Studies on Urolithin A and Cancer&lt;/p&gt; &lt;p dir="ltr"&gt;30:01 Clinical Trials and Future Directions&lt;/p&gt; &lt;p dir="ltr"&gt;31:17 Understanding the Immune System&lt;/p&gt; &lt;p dir="ltr"&gt;33:54 The Mitoimmune Randomized Control Trial&lt;/p&gt; &lt;p dir="ltr"&gt;38:31 Dosing and Effects of Urolithin A&lt;/p&gt; &lt;p dir="ltr"&gt;40:22 Biological Age Reversal and Longevity&lt;/p&gt; &lt;p dir="ltr"&gt;44:33 Combining Strategies for Enhanced Benefits&lt;/p&gt; &lt;p dir="ltr"&gt;49:21 Future Research Directions in Cancer and Neurodegeneration&lt;/p&gt; &lt;p&gt;&lt;strong&gt;&lt;br /&gt; &lt;br /&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;Studies Mentioned: &lt;/p&gt; &lt;p dir="ltr"&gt;&lt;a href= "https://www.nature.com/articles/s43587-023-00473-3"&gt;Mitochondrial Recycling Reverts Age-Associated Decline&lt;/a&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;&lt;a href= "https://aacrjournals.org/cancerrescommun/article/4/5/1189/745142/Urolithin-A-Promotes-CD8-T-Cell-mediated-Cancer"&gt; Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance&lt;/a&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;&lt;a href= "https://pubmed.ncbi.nlm.nih.gov/36351375/"&gt;Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy&lt;/a&gt;&lt;/p&gt; &lt;p dir="ltr"&gt;&lt;a href= "https://drive.google.com/file/d/1NL1DDqZ42dBTMdQzXg8WuizkVDDZ3dAM/view?usp=sharing"&gt; Mitopure Impact on Immune Aging: RCT&lt;/a&gt;&lt;/p&gt; &lt;p&gt; &lt;/p&gt;</description>

LONGEVITY with Nathalie Niddam

Nathalie Niddam

Episode #279: Dr. Anurag Singh: Urolithin A, the Aging Immune System, Biological Age Reversal and more…

OCT 25, 202463 MIN
LONGEVITY with Nathalie Niddam

Episode #279: Dr. Anurag Singh: Urolithin A, the Aging Immune System, Biological Age Reversal and more…

OCT 25, 202463 MIN

Description

Are you protecting your immune system as you age?

 

In this Longevity podcast episode, I am joined by Dr. Anurag Singh to discuss recent research that suggests Urolithin A, a compound derived from pomegranates and other foods, may help rejuvenate the aging immune system. 

 

We dive into how supplementing with Urolithin A for just 4 weeks led to significant improvements in immune cell function and a reduction in biological age by an average of 2 years in middle-aged adults. We also discuss insights on dosing, combining Urolithin A with other longevity strategies, and ongoing clinical trials that may reveal even more benefits.

 

Dr. Anurag Singh is the Chief Medical Officer of Timeline Nutrition, a biotech company focused on discovering and developing next generation natural compounds that target improvement in mitochondrial health. He began his career in 2003 as a Resident Medical Doctor at Northern Railway Divisional Hospital in Lucknow. 

 

Go to TimelineNutrition.com/nat10 and/or use code Nat10 for a discount.

 

Thank you to our sponsors for making this episode possible:                                                                                                                                                          

Element Health: Use code Longevity when shopping at https://elementhealthsupply.com/discount/Longevity  to save on your orders.

Siphox: Visit http://SiPhoxhealth.com/nat  and save on your test. 

                                                                                                                                           

Find more from Dr. Singh/Timeline: 

Website: www.timelinenutrition.com 

Instagram: @timeline_longevity

 

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ 

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community 

Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 

Instagram: https://www.instagram.com/nathalieniddam/ 

Website: www.NatNiddam.com   

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance 

 

What We Discuss:

 

09:04 The Role of the Immune System in Aging

12:10 Understanding Immune Exhaustion and Inflammation

15:12 Mitochondrial Health and Immune Function

18:06 Urolithin A: Sources and Production

12:05 Research Studies on Urolithin A and Cancer

30:01 Clinical Trials and Future Directions

31:17 Understanding the Immune System

33:54 The Mitoimmune Randomized Control Trial

38:31 Dosing and Effects of Urolithin A

40:22 Biological Age Reversal and Longevity

44:33 Combining Strategies for Enhanced Benefits

49:21 Future Research Directions in Cancer and Neurodegeneration

Studies Mentioned: 

Mitochondrial Recycling Reverts Age-Associated Decline

Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Mitopure Impact on Immune Aging: RCT