<p>FSUの吉良信一郎さん(<a href="https://x.com/shinichirokira" target="_blank" rel="ugc noopener noreferrer">@ShinichiroKira</a>)ゲスト回。UW Shadlen研への留学、サル電気生理からマウス(HMS Harvey研)へ、新たなラボでの研究の方向性など (10/5 収録)</p><p><br></p><p>Show Notes (<a href="https://neuroradio.tokyo/2025/10/23/99-generalization/" target="_blank" rel="noopener noreferer">番組HP</a>):</p><ul><li><a href="https://www.kiralab.org/" target="_blank" rel="ugc noopener noreferrer">Florida State University吉良ラボHP</a>Florida State University (FSU)で新たに研究室を立ち上げました。脳が過去の経験をもとに、新しい環境でどのように適切な意思決定を行うか (Generalization) にフォーカスして研究を進めていく予定です。熱意あるポスドク・大学院生を募集しています。ご興味のある方は、ぜひお気軽にご<a href="mailto:[email protected]" target="_blank" rel="ugc noopener noreferrer">連絡</a>ください！</li><li><a href="https://neuroradio.tokyo/2022/10/06/46-the-fos-expression-we-saw-that-day/" target="_blank" rel="ugc noopener noreferrer">NRジャーナルクラブ回</a></li><li><a href="https://lakeconferences.org/" target="_blank" rel="ugc noopener noreferrer">Lake Conferences</a></li><li><a href="https://en.wikipedia.org/wiki/Florida_panhandle" target="_blank" rel="ugc noopener noreferrer">Florida Panhandle</a></li><li><a href="https://ja.wikipedia.org/wiki/%E3%82%BF%E3%83%A9%E3%83%8F%E3%82%B7%E3%83%BC_(%E3%83%95%E3%83%AD%E3%83%AA%E3%83%80%E5%B7%9E)" target="_blank" rel="ugc noopener noreferrer">タラハシー市</a></li><li>シアトルのあるワシントン州の州都は<a href="https://ja.wikipedia.org/wiki/%E3%82%AA%E3%83%AA%E3%83%B3%E3%83%94%E3%82%A2_(%E3%83%AF%E3%82%B7%E3%83%B3%E3%83%88%E3%83%B3%E5%B7%9E)" target="_blank" rel="ugc noopener noreferrer">オリンピア</a>。タコマは軍基地がある。</li><li><a href="https://www.fsu.edu/" target="_blank" rel="ugc noopener noreferrer">Florida State University フロリダ州立大学</a></li><li><a href="https://hattori.scripps.ufl.edu/" target="_blank" rel="ugc noopener noreferrer">服部さん</a> (Scripps, <a href="https://www.ufl.edu/" target="_blank" rel="ugc noopener noreferrer">The University of Florida フロリダ大学</a>)</li><li><a href="https://en.wikipedia.org/wiki/Florida%E2%80%93Florida_State_football_rivalry" target="_blank" rel="ugc noopener noreferrer">Seminoles (FSU) vs Gators (UF)</a></li><li><a href="https://www.iqb.u-tokyo.ac.jp/okuyamalab/" target="_blank" rel="ugc noopener noreferrer">奥山 輝大さん</a> (東大 定量研)</li><li><a href="https://kitazawa-lab.jp/" target="_blank" rel="ugc noopener noreferrer">北沢 茂先生</a> (現・阪大)</li><li><a href="https://www.med.yamanashi.ac.jp/basic/integphys/greeting.html" target="_blank" rel="ugc noopener noreferrer">宇賀 貴紀先生</a>(現・山梨大)</li><li><a href="https://github.com/amitani" target="_blank" rel="ugc noopener noreferrer">三谷 明範さん</a>(Komiyama研PhD-&gt;Google-&gt;-Artera&gt;Apple)の<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059670" target="_blank" rel="ugc noopener noreferrer">宇賀研での仕事</a></li><li><a href="https://www.jneurosci.org/content/12/6/2331" target="_blank" rel="ugc noopener noreferrer">Saltzman/Newsome1992</a> 最近の2光子Stim論文とかでこれを引いてないのはモグリだと思ってる(萩)</li><li>Shadlen Newsome <a href="https://www.jneurosci.org/content/18/10/3870.short" target="_blank" rel="ugc noopener noreferrer">1998</a> <a href="https://journals.physiology.org/doi/full/10.1152/jn.2001.86.4.1916?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org" target="_blank" rel="ugc noopener noreferrer">2001</a> </li><li>一番刺さった<a href="https://www.jneurosci.org/content/16/4/1486.long" target="_blank" rel="ugc noopener noreferrer">Shadlen et al 1996</a> (吉良)</li><li>Goldman-Rakicの<a href="https://www.nature.com/articles/nn1003-1015" target="_blank" rel="ugc noopener noreferrer">obituary</a> in Nature. <a href="https://journals.physiology.org/doi/abs/10.1152/jn.1989.61.2.331?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org" target="_blank" rel="ugc noopener noreferrer">Funahashi/Goldman-Rakic1989</a>が特によい(萩) </li><li><a href="https://scholar.google.com/citations?user=aK4K5e8AAAAJ&hl=en" target="_blank" rel="ugc noopener noreferrer">Logothetis</a> いまは中国にいる</li><li>チュービンゲンのゴタゴタ <a href="https://www.nature.com/articles/d41586-018-07868-y" target="_blank" rel="ugc noopener noreferrer">Natureの記事</a>、<a href="https://www.science.org/content/article/animal-rights-conflict-prompts-leading-researcher-leave-germany-china" target="_blank" rel="ugc noopener noreferrer">Scienceの記事</a></li><li><a href="https://zuckermaninstitute.columbia.edu/richard-axel-md" target="_blank" rel="ugc noopener noreferrer">Richard Axel</a></li><li><a href="https://tsaolab.berkeley.edu/" target="_blank" rel="ugc noopener noreferrer">Doris Tsao</a>の<a href="https://elifesciences.org/articles/74394" target="_blank" rel="ugc noopener noreferrer">マウス</a>、<a href="https://www.nature.com/articles/s41586-025-09441-w" target="_blank" rel="ugc noopener noreferrer">Tree shrew</a>の仕事</li><li><a href="https://www.visualneurolab.sissa.it/" target="_blank" rel="ugc noopener noreferrer">Davide Zoccolan</a></li><li><a href="https://mcgovern.mit.edu/profile/james-dicarlo/" target="_blank" rel="ugc noopener noreferrer">Jim Dicarlo</a></li><li><a href="https://shadlenlab.zi.columbia.edu/" target="_blank" rel="ugc noopener noreferrer">Michael Shadlen</a></li><li><a href="https://www.neuroeconomicslab.org/" target="_blank" rel="ugc noopener noreferrer">Paul Glimcher</a></li><li><a href="https://www.vis.caltech.edu/" target="_blank" rel="ugc noopener noreferrer">Richard Andersen</a></li><li><a href="https://mr.research.columbia.edu/content/michael-e-goldberg" target="_blank" rel="ugc noopener noreferrer">Michel Goldberg</a></li><li><a href="https://www.gottlieblab.com/" target="_blank" rel="ugc noopener noreferrer">Jacqueline Gottlieb</a></li><li><a href="https://profiles.stanford.edu/william-newsome" target="_blank" rel="ugc noopener noreferrer">Bill Newsome</a></li><li><a href="https://www.nature.com/articles/nature12742" target="_blank" rel="ugc noopener noreferrer">Mante, Sussilo, Shenoy, Newsome</a></li><li><a href="https://sites.krieger.jhu.edu/daeyeol-lee-lab/" target="_blank" rel="ugc noopener noreferrer">Daeyeol Lee</a> この<a href="https://www.nature.com/articles/nn2065" target="_blank" rel="ugc noopener noreferrer">GameTheory/Social Decision-Makingの総説</a>の印象が強い(萩)</li><li><a href="https://www.cns.nyu.edu/wanglab/" target="_blank" rel="ugc noopener noreferrer">Xiao Jing Wang</a></li><li>そういえばLIPあんまり重要でなさそうという<a href="https://www.nature.com/articles/nature18617" target="_blank" rel="ugc noopener noreferrer">AlexHuk論文</a>を議論してもよかったなと思いました。その後の展開をちゃんと追ってないので、LIP詳しい人のコメントを聞いてみたかったのでもしよかったらここで。(萩)</li><li><a href="https://www.science.org/doi/10.1126/science.aaw8347" target="_blank" rel="ugc noopener noreferrer">Zhou &amp; Freedman</a> は抑制したLIPの応答視覚領域(Response Field)の中に視覚刺激(ランダムドット)がある場合とターゲットがある場合を比較して、前者の方が後者より正答率が顕著に低下することを示しました。LIP抑制ではないですが、<a href="https://elifesciences.org/articles/36523" target="_blank" rel="ugc noopener noreferrer">Fetsch et al </a>はMTが抑制されても残存領域の代替により、意思決定機能は速やかに回復することを示しました。同様の現象は齧歯類でも報告があります(<a href="http://dx.doi.org/10.1016/j.neuron.2015.03.024" target="_blank" rel="ugc noopener noreferrer">Kawai et al</a>, <a href="https://www.nature.com/articles/s41593-024-01792-3" target="_blank" rel="ugc noopener noreferrer">Mizes et al</a>, <a href="https://www.nature.com/articles/s41586-024-07799-x" target="_blank" rel="ugc noopener noreferrer">Hong et al</a>, <a href="https://www.biorxiv.org/content/10.1101/2023.05.11.540397v2" target="_blank" rel="ugc noopener noreferrer">Quintana et al</a>)。私自身も実験を通じて経験しており、<a href="https://www.kiralab.org/research" target="_blank" rel="ugc noopener noreferrer">今後の研究テーマ</a>(脳の機能回復メカニズム)として掲げています。(吉良)</li><li><a href="https://depts.washington.edu/fetzweb/" target="_blank" rel="ugc noopener noreferrer">Eb Fetz</a> (UW)</li><li><a href="https://www.cns.nyu.edu/kianilab/Home.html" target="_blank" rel="ugc noopener noreferrer">Roozbeh Kiani</a> (NYU)</li><li><a href="https://hankslab.faculty.ucdavis.edu/" target="_blank" rel="ugc noopener noreferrer">Tim Hanks</a> (UC Davis)</li><li><a href="https://churchlandlab.dgsom.ucla.edu/" target="_blank" rel="ugc noopener noreferrer">Anne Churchland</a> (UCLA)</li><li><a href="https://jazlab.org/" target="_blank" rel="ugc noopener noreferrer">Mehrdad Jazayeri</a> (MIT)</li><li><a href="https://www.med.upenn.edu/goldlab/" target="_blank" rel="ugc noopener noreferrer">Josh Gold</a> (U Penn)</li><li><a href="http://english.cebsit.cas.cn/lab/yangtianming/research/#" target="_blank" rel="ugc noopener noreferrer">Tianming Yang</a> (ION 中国科学院 )</li><li><a href="https://www.nature.com/articles/nature05852" target="_blank" rel="ugc noopener noreferrer">Probabilistic reasoning by neurons</a></li><li><a href="https://www.sciencedirect.com/science/article/pii/S0896627315000082" target="_blank" rel="ugc noopener noreferrer">Neural Implementation of Wald’s Sequential Probability Ratio</a></li><li><a href="https://www.jneurosci.org/content/12/12/4745" target="_blank" rel="ugc noopener noreferrer">ランダムドットタスク</a></li><li>今年出した<a href="https://www.jneurosci.org/content/45/31/e2426242025.abstract" target="_blank" rel="ugc noopener noreferrer">ヒトのPsychophysics論文</a></li><li><a href="https://www.osti.gov/biblio/5213621" target="_blank" rel="ugc noopener noreferrer">NIH Rex</a></li><li><a href="https://www.psychopy.org/" target="_blank" rel="ugc noopener noreferrer">PsychoPy</a></li><li><a href="https://en.wikipedia.org/wiki/Real-time_operating_system" target="_blank" rel="ugc noopener noreferrer">リアルタイムOS</a></li><li><a href="https://www.nature.com/articles/nature12160" target="_blank" rel="ugc noopener noreferrer">Mixed Selectivity 論文</a></li><li><a href="https://www.moorelabstanford.com/" target="_blank" rel="ugc noopener noreferrer">Tirin Moore</a></li><li><a href="https://en.wikipedia.org/wiki/Frontal_eye_fields" target="_blank" rel="ugc noopener noreferrer">FEF</a>:Frontal eye field,眼球運動に対応する運動野だがselective attentionもやっている</li><li><a href="https://www.nature.com/articles/s41593-025-01976-5" target="_blank" rel="ugc noopener noreferrer">NHP Neuropixel</a></li><li><a href="https://www.science.org/doi/abs/10.1126/science.aaa4056" target="_blank" rel="ugc noopener noreferrer">Stepping</a>と<a href="https://www.science.org/doi/10.1126/science.aad3242" target="_blank" rel="ugc noopener noreferrer">Ramping</a>の議論</li><li><a href="https://elifesciences.org/articles/90859" target="_blank" rel="ugc noopener noreferrer">Neuropixel記録論文</a>: Drift-Diffusion Modelの実証</li><li><a href="https://buffalomemorylab.com/" target="_blank" rel="ugc noopener noreferrer">Elizabeth Baffalo</a></li><li><a href="https://link.springer.com/article/10.1007/BF00271862" target="_blank" rel="ugc noopener noreferrer">Memory-Guided Saccade Task</a></li><li><a href="https://ctn.zuckermaninstitute.columbia.edu/people/stefano-fusi" target="_blank" rel="ugc noopener noreferrer">Stefano Fusi</a></li><li><a href="https://www.nature.com/articles/nature12160" target="_blank" rel="ugc noopener noreferrer">Rigotti et al</a> (Mixed selectivity)</li><li><a href="https://www.sciencedirect.com/science/article/pii/S0092867420312289" target="_blank" rel="ugc noopener noreferrer">Barnerdi et al</a> (CCGP: Cross Condition Generalization Performance)</li><li><a href="https://en.wikipedia.org/wiki/Schema_(psychology)" target="_blank" rel="ugc noopener noreferrer">Schema</a>を使った<a href="https://www.sciencedirect.com/science/article/pii/S0959438822001350?via%3Dihub" target="_blank" rel="ugc noopener noreferrer">Categorizationの簡潔な総説を五十嵐さんが書いている</a></li><li><a href="https://www.annualreviews.org/content/journals/10.1146/annurev.neuro.051508.135256" target="_blank" rel="ugc noopener noreferrer">Saltzman &amp; Fusi</a></li><li><a href="https://www.nature.com/articles/s41586-024-07799-x" target="_blank" rel="ugc noopener noreferrer">Courellis et al</a> (ヒトの神経活動をCCGPで解析)</li><li><a href="https://www.losonczylab.org/" target="_blank" rel="ugc noopener noreferrer">Attila Losonczy</a>  (現在はUniversity of Texas South Western)</li><li><a href="https://ctn.zuckermaninstitute.columbia.edu/people/larry-f-abbott" target="_blank" rel="ugc noopener noreferrer">Larry Abbott</a></li><li><a href="https://ctn.zuckermaninstitute.columbia.edu/Ken" target="_blank" rel="ugc noopener noreferrer">Ken Miller</a></li><li><a href="https://sites.stat.columbia.edu/liam/" target="_blank" rel="ugc noopener noreferrer">Liam Paninski</a></li><li><a href="https://alleninstitute.org/events/data-driven-discovery-ai-and-modeling-in-biology/" target="_blank" rel="ugc noopener noreferrer">Allen D3</a></li><li><a href="https://alleninstitute.org/person/laura-driscoll/" target="_blank" rel="ugc noopener noreferrer">Laura Driscoll</a></li><li><a href="https://dawlab.princeton.edu/" target="_blank" rel="ugc noopener noreferrer">Nathaniel Daw</a></li><li><a href="https://www.mpg.de/12309370/biological-cybernetics-dayan" target="_blank" rel="ugc noopener noreferrer">Peter Dayan</a></li><li><a href="https://www.imagwiki.nibib.nih.gov/content/thalamus-middle-computations-multi-regional-neural-circuits" target="_blank" rel="ugc noopener noreferrer">ThalamusのU-19 Grant</a></li><li><a href="https://www.druckmannlab.com/" target="_blank" rel="ugc noopener noreferrer">Shaul Druckmann</a></li><li><a href="https://neuroradio.tokyo/2024/02/20/72-collaborative-professionalism-in-neuroscience/" target="_blank" rel="ugc noopener noreferrer">大久保 達夫さん NR出演回</a></li><li><a href="https://neuroradio.tokyo/2021/06/28/16-mechanistic-vs-population-codes-inter-show-interaction-with-ayaka-kato/" target="_blank" rel="ugc noopener noreferrer">加藤 郁佳さん NR出演回</a></li><li><a href="https://harveylab.hms.harvard.edu/" target="_blank" rel="ugc noopener noreferrer">Chris Harvey</a></li><li><a href="https://www.nature.com/articles/nature10918" target="_blank" rel="ugc noopener noreferrer">HarveyTank 2012</a> 2012年3月なのでまさにSalk滞在中に出版されて読んでた(萩)</li><li>HattoriさんのRSCの論文 (<a href="https://doi.org/10.1016/j.cell.2019.04.027" target="_blank" rel="ugc noopener noreferrer">Hattori 2019</a>)</li><li>JeremiahのmPFCの論文 (<a href="https://doi.org/10.1016/j.neuron.2019.06.001" target="_blank" rel="ugc noopener noreferrer">Bari 2019</a>)</li><li><a href="https://en.wikipedia.org/wiki/Default_mode_network" target="_blank" rel="ugc noopener noreferrer">Default mode network</a></li><li><a href="https://en.wikipedia.org/wiki/Match-to-sample_task" target="_blank" rel="ugc noopener noreferrer">Delay (non) match to sample task</a></li><li><a href="https://doi.org/10.1016/j.neuron.2020.01.034" target="_blank" rel="ugc noopener noreferrer">ShadlenのOdorの論文</a></li><li><a href="https://www.sciencedirect.com/science/article/pii/S0896627320301033" target="_blank" rel="ugc noopener noreferrer">JerryChenのS1/S2の論文</a>, <a href="https://www.science.org/doi/10.1126/science.abl5981" target="_blank" rel="ugc noopener noreferrer">S1しか見てない論文</a></li><li><a href="https://www.nature.com/articles/s41586-022-05014-3" target="_blank" rel="ugc noopener noreferrer">Voitov &amp; Mrsic-Flogel論文</a> ちなみに前述のLosonczy研にいてNYに残った知り合いというのはこのIvan(萩)</li><li><a href