<p>Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing.</p><p><br></p><p>In this conversation, Dr. Charles Brenner, professor at City of Hope and discoverer of nicotinamide riboside&#39;s therapeutic uses, challenges common assumptions about NAD and aging. He explains why blood NAD stays stable throughout life and how metabolic stress - not aging - depletes the NAD system.</p><p><br></p><p>Dr. Brenner discusses Northwestern University&#39;s landmark peripheral artery disease trial where NR improved walking speed while placebo patients declined, why metformin failed the same test, and the eight randomized clinical trials showing NR&#39;s anti-inflammatory effects. We explore COVID-19&#39;s impact on NAD, why NMN may cause neurodegeneration, optimal NR dosing (300mg-1g daily), and bioavailability questions.</p><p>He dismantles the biological age testing industry with evidence showing DNA methylation tests measure inflammation, not aging. Learn why Kaiser Permanente ignores trendy biomarkers, which supplements lack safety data, and the evidence-based approach to NAD supplementation for conditions like wound healing, heart failure, and Parkinson&#39;s disease.</p><p><br></p><p>🌐Links in this video </p><p>Dr Brenner&#39;s home page https://www.cityofhope.org/research/find-a-scientist/charles-brenner</p><p>X (Twitter) https://x.com/CharlesMBrenner/</p><p><br></p><p>Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO</p><p>AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw</p><p>https://www.choosemuse.com</p><p>Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)</p><p>Renue by Science all 10% discount with code MHS https://renuebyscience.com/ </p><p>Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN</p><p>If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan</p><p>You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan</p><p><br></p>