What’s Driving Inflammation in Autism? | Essentials with Dr. Horowitz

What’s driving inflammation in autism? In this Biohacking Autism Essentials edition, Dr. Richard Horowitz walks through the core ideas from his 16-point MSIDS framework and explains how multiple biological systems may contribute to chronic inflammation and symptoms in autism. This shorter, focused edition covers: • The 16-point MSIDS framework • The six “rivers of inflammation” • Neuroinflammation and microglial activation • Gut health, leaky gut, and the microbiome • Mast cell activation and histamine • Mitochondrial dysfunction and the cell danger response • Lyme disease and Bartonella • POTS, dysautonomia, and hypermobility • Autism biomarkers including NfL, GFAP, CRP, VEGF, tau, and p-tau • Why different children may have very different biological drivers Dr. Horowitz’s MSIDS framework was developed for complex chronic illness, not specifically for autism. In this conversation, he explains how he believes the framework may help families and clinicians think more broadly about overlapping contributors to inflammation and chronic symptoms. This is the shorter Essentials edition. For the complete technical discussion, listen to the Full Episode with Dr. Richard Horowitz. CONNECT WITH DR. RICHARD HOROWITZ Get Dr. Horowitz’s new book, Ending Chronic Illness: https://cangetbetter.com/ending-chronic-illness/ Website: https://cangetbetter.com/ Medical Detective Substack: https://medicaldetective.substack.com/ Horowitz Lyme-MSIDS Questionnaire: https://msidsfoundation.org/questionnaire/ For physicians with questions about complex cases: [email protected] MEDICAL DISCLAIMER This episode is for educational and informational purposes only. It is not medical advice, diagnosis, or treatment. Always discuss testing and treatment decisions with a qualified healthcare professional. This podcast uses the following third-party services for analysis: OP3 - https://op3.dev/privacy