At the A4M Conference, Sean Kelly sits down with Dr. Lucia Aronica (Stanford lecturer + nutrigenomics/epigenetics researcher) to break down how food “talks” to your genes — and why most people are missing the nutrients that actually run the “software.” They debunk the cholesterol + eggs myth, explain why choline is a forgotten essential nutrient, and introduce Dr. Lucia’s practical framework for “epi-nutrition”: using specific foods to flip epigenetic switches that support brain health, metabolism, inflammation, and longevity. 🎯 What You’ll Learn 🧬 How the epigenome acts like software that turns genes on/off 🍳 Why egg yolks + cholesterol fear is mostly outdated science 🧠 Why choline matters for brain, liver, and gene regulation 🥗 How to build meals that support gene expression (protein + plants) 🧫 What fermented foods do (pre/pro/postbiotics) ⚖️ What the Stanford twin study results do and don’t prove 🔥 How weight gain creates an epigenetic “fat memory” (and how it fades) Chapters (Timestamps) 0:00 – The cholesterol myth (eggs aren’t the villain) 0:32 – Meet Dr. Lucia Aronica at A4M 0:53 – DNA hardware vs epigenome software 1:28 – “Epi-nutrition”: nourishing genes with food 2:24 – The “usual suspects”: protein + colorful plants + fermented foods 4:30 – Why animal protein matters (B12 + choline) 5:09 – Choline: the forgotten essential nutrient + the “4-yolk formula” 9:59 – Microplastics, salmon, and the 80/20 approach 12:04 – Stanford data: dietary cholesterol vs blood cholesterol 14:07 – Twin study takeaways + long-term vegan caveats (B12/choline) 🎙️ APPLY OR CONNECT 👉 Interested in being a guest? Apply here: https://www.digitalsocialhour.com/application 💼 SPONSORS 🥗 Fuel your health with Viome: https://buy.viome.com/SEAN Use code “Sean” at checkout for a discount! 📩 Business Inquiries & Sponsorships [email protected] 👤 GUEST Lucia Aronica: https://www.instagram.com/drluciaaronica/? 🎧 LISTEN TO THE PODCAST 🍏 Apple Podcasts: https://podcasts.apple.com/us/podcast/digital-social-hour/id1676846015 🎵 Spotify: https://open.spotify.com/show/5Jn7LXarRlI8Hc0GtTn759 📸 Follow the Host Sean Kelly on Instagram: @seanmikekelly ⚠️ DISCLAIMER The views and opinions expressed by guests on Digital Social Hour are their own and do not necessarily reflect those of the host, Sean Kelly, or the Digital Social Hour team. The host and producers are not responsible for statements, claims, or opinions shared by guests during the show. This content is intended for informational and entertainment purposes only and should not be considered legal, medical, financial, or professional advice. Listeners are encouraged to do their own research and consult qualified professionals when appropriate. While we aim to share accurate and reliable information, no guarantees are made regarding completeness or accuracy. 🔥 Stay tuned for more conversations with creators, founders, and innovators shaping the digital world. Keywords Dr. Lucia Aronica, Lucia Aronica, nutritional epigenetics, nutrigenomics, epigenome, gene expression, choline, egg yolks, cholesterol myth, Stanford study, twin study, You Are What You Eat, A4M conference, Sean Kelly Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.