Wellbutrin (Bupropion) vs Trintellix (Vortioxetine) After SSRI Failure | PMHNP Boards

💎 Go beyond the episode — study guides, psychopharm deep dives & practice questions: https://www.patreon.com/PearlsandPrep 🎁 Join as a free member to access 50 Pearls from Pearls & Prep — 50 super high-yield pearls to sharpen your practice. 📚 The 100 Psychiatric Interview Tips For Your 1st Eval E-Book is $39.99 in the shop — or get it FREE as a Boss Pearl member: https://www.patreon.com/c/pearlsandprep/shop ⭐ Enjoying the show? Please rate and review Pearls and Prep on Apple Podcasts or Spotify — it really helps! 🌐 PearlsandPrep.com — scan this episode's Street Takes card, read the deep-dive articles, and unlock the full clinical library: https://pearlsandprep.com ✉️ Questions or a case you want covered? Write to NP Z: [email protected] When depression lifts on an SSRI but joy, motivation, and emotional range stay flat, is it residual depression or SSRI-induced emotional blunting? This episode compares bupropion (Wellbutrin) and vortioxetine (Trintellix) for exactly that stuck moment in practice. You will learn the psychopharmacology reasoning that separates the two, sharpening your differential diagnosis skills and building clinical confidence for PMHNP boards — so you understand the why before you switch. 🎧 Pearls & Prep — new episodes every Tuesday. Hosted by NP Z, Duke-trained Psychiatric Nurse Practitioner. ⚖️ Disclaimer: Pearls and Prep is an educational podcast and is not medical advice. All views expressed are exclusively those of NP Z and do not represent — and are not endorsed by — any other entity or organization. These perspectives are offered solely to build conceptual appreciation of psychiatric topics; they are not a substitute for clinical judgment, current clinical guidelines, or primary references. Always use appropriate resources and your own clinical judgment when making decisions about individual patients. Nothing in this episode creates a clinician–patient relationship. This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy