Dr Manuel Corpas presents the HEIM framework and Bias Amplification Cascade at the Molecular Science Research Hub seminar (12 March 2026). The talk covers three dimensions of compounding neglect in biomedical research: discovery (70 biobanks, 38,595 publications), translation (563,725 clinical trials), and knowledge (13.1M PubMed abstracts). Key findings: no neglected tropical disease has generated a single biobank publication; 93.5% of biobank research comes from high-income countries; and structural metrics predict 66.6% of LLM performance variance across 175 diseases. Six frontier LLMs benchmarked on 10,500 standardised queries show identical blind spots, proving the bias originates in shared training data, not model architecture. The talk concludes with the HIV/AIDS case as proof that sustained investment can reverse semantic isolation.