Manuel narrates his UK DRI seminar at Imperial College London (29 April 2026): how agentic genomics shifts the bottleneck from pipeline construction to validation. An empirical benchmark of 8 frontier LLMs across 1,728 evaluations on the ClawBio pharmgx-reporter skill: 92.4% mean phenotype accuracy without specification, 100% with specification, and a 6 of 7 lethal-error gap that closes only when population-aware skill data is engineered in.